Rapid construction of the tricyclic cores of the abietane- and icetexane-type diterpenoids
Rapid construction of the tricyclic cores of the abietane- and icetexane-type diterpenoids
摘要
A short synthesis of the tricyclic 6-6-6 and 6-7-6 ring systems of the abietane- and icetexane-type diterpenoids from a common intermediate is presented, using alkylation and acid-catalyzed cyclization as key steps.
A short synthesis of the tricyclic 6-6-6 and 6-7-6 ring systems of the abietane- and icetexane-type diterpenoids from a common intermediate is presented, using alkylation and acid-catalyzed cyclization as key steps.
基金
the financial support provided by the National Science Foundation of China(No.30873147)
参考文献13
-
1E.M. Simmons, R. Sarpong, Nat. Prod. Rep. 26 (2009) 1195.
-
2Y. Suto, K. Kaneko, N. Yamagiwa, et al. Tetrahedron Lett. 51 (2010) 6329.
-
3N.W. Jan, H.J. Liu, M.T. Hsieh, et al. Eur. J. Org. Chem. 2010 (2010) 4271.
-
4A. Carita, A.C.B, Burtoloso, Tetrahedron Lett. 51 (2010) 686.
-
5F. de, J. Cortez, R. Sarpong, Org. Lett. 12 (2010) 1428.
-
6G. Majetich, J.L. Grove, Org. Lett. 11 (2009) 2904.
-
7C.E. Hartmann, P.J. Gross, M. Niegerb, et al. Org. Biomol. Chem. 7 (2009) 5059.
-
8Compound 9: colorless needle crystals, nap 99-100 ℃, IR (KBr): 2929, 1595, 1488, 1463, 1319, 1080 cm-1.
-
9IH NMR (400 MHz, CDCI3): 81.62-1.68 (m, 4H), 1.96 (t, 2H, J = 8.0 Hz), 2.19 (s, 2H), 2.53 (s, 2H), 2.66 (t, 2H, J = 7.6 Hz), 3.72 (s, 3H), 3.78 (s, 3H), 3.86 (s, 3H), 6.38 (s,3H).
-
1013C NMR (100 MHz, CDC13): 3 22.01 (CH2), 22.95 (CH2), 23.97 (CH2), 28.40 (CH2), 31.26 (CH2), 55.79 (CH3), 56.23 (CH3), 60.58 (CH3),119.73 (CH), 127.28 (C), 132.23 (C), 133.07 (C), 139.50 (C), 150.93 (C), 152.72 (C). HR-ESIMS: m/z: C17H2303 [M+H]+ 275.1637 (calcd. 275.1647).
-
1倪步高.NE型多功能镀镍添加剂[J].电镀与环保,1998,18(3):9-11.
-
2边明祥.GF型高效复合水泥助磨剂对水泥物性的影响试验[J].水泥工程,2010(6):27-30.
-
3吴述军,杜志清,张进才,孙广伦.依靠科学管理 尽快完成九矿改扩建工程[J].煤矿现代化,2005(4):20-21.
-
4杨改成.NE提升机在输送水泥粉料时的改造[J].水泥,2006(4):57-57.
-
5高性能建筑结构胶粘剂在武汉问世[J].企业科技与发展,2009(7):5-6.
-
6崔秀娥,郝长青,李景旺.NE型提升机下链轮轴承座脱轨解决方案[J].水泥,2013(10):31-31.
-
7Ren Yi Yan,Ruo Yun Chen,De Quan Yu.Two new diterpenoids from Suregada glomerulata(Blume) Baill[J].Chinese Chemical Letters,2011,22(5):580-582. 被引量：1
-
8Li Wang,Zhen Zang,Yu-Fei Wang,Sheng-Xiong Huang,Pei Cao,Yong Zhao.Two new myrinsol diterpenoids from Euphorbia dracunculoides Lam.[J].Chinese Chemical Letters,2015,26(1):121-123. 被引量：2
-
9Sheng Guo Yu Ping Tang Jin Ao Duan Shu Lan Su An Wei Ding.Two new terpenoids from fruits of Ziziphus jujuba[J].Chinese Chemical Letters,2009,20(2):197-200. 被引量：15
-
10天然产物分析鉴定[J].天然产物分离,2004,2(2):33-37.
