摘要
目的 研究老年大鼠神经、内分泌、血液流变学的改变 ,探讨衰老的发病机理及中药开心散益智抗衰老的作用机理。 方法 用 2 1月龄大鼠作为衰老模型 ,并用中药开心散进行治疗 ;6月龄大鼠为青年对照组。测定血浆皮质醇、血液流变学及脑内单胺类神经递质的含量变化。 结果 老年大鼠血浆皮质醇含量较高 ;全血和血浆粘度明显升高 ;脑内多巴胺 (DA)含量明显降低 ,去甲肾上腺素 (NE)、5 羟吲哚乙酸 ( 5 HIAA)亦有下降 ,5 羟色胺 ( 5 HT)升高。应用开心散后老年大鼠皮质醇含量下降 ;血液粘度改善 ;脑组织DA、NE、5 HIAA含量升高 ,5 HT含量降低。 结论 2 1月龄大鼠可作为衰老动物模型 ;衰老的形成与神经、内分泌、血液流变学改变等综合因素有关 ;中药开心散具有延缓衰老的作用 ,其抗衰老作用可能与改善大鼠下丘脑 垂体 肾上腺轴功能衰退和血液流变性有关。
To study the change of neuron,endocrine and blood rheological property in old rats.To inquire into the pathologic mechanism of senility,and the effect and mechanism of “Kai Xin San”(KXS)in improving memory and preventing senility. Methods In the experiment,21 month old rats were used as the models for the aged and were treated with KXS;6 month old rats were used as the young control group.The blood plasma corticosterone was measured and the change of blood rheological property and brain monoamine neurotransmitters were observed. Results The old rats had a fairly high level of blood plasma corticosterone.There was an increase in whole blood,blood viscosity,and 5 hydroxytryptamine(5 HT)and a significant decrease in dopamina(DA),and a lowering of norepinephrine(NE),and 5 hydroxyindole acetic acid(5 HIAA)in these old rats.KXS reduced plasma corticosterone and 5 HT,improved blood viscosity,and increased brain DA,NE,5 HIAA. Conclusions 21 momth old rats can be used the models for the aged.Senility is caused by many factors such as the change of neuron,endocrine and blood rheological property.KXS is effective in delaying senility and its effect may be due to the resistance against hypofunction of the thalamencephal hypophysis adrenal gland axis,and the improvement of blood rheological property.
出处
《实用老年医学》
CAS
1999年第6期306-308,共3页
Practical Geriatrics
关键词
衰老
抗衰老
皮质醇
血液流变学
开心散
Senility/Anti senility Corticosterone Blood rheological property Monoamine neurotransmitter Thalamencephal hypophysis adrenal gland axis Kai Xin San
