摘要
目的比较分析3种不同放疗技术治疗鼻腔NK/T细胞淋巴瘤的剂量学差异,为临床治疗提供依据。方法选取6例鼻腔NK/T细胞淋巴瘤患者,应用三维治疗计划系统(TPS)分别为每例患者设计3种治疗计划,即常规放疗(CRT)、三维适形放疗(3D-CRT)和调强适形放疗(IMRT),对CRT要求参考点达到处方剂量54Gy,对3D-CRT和IMRT要求95%的等剂量线(54Gy)包括整个计划靶体积(PTV)。根据等剂量曲线及剂量体积直方图(DVH)比较3种计划靶区剂量分布及危及器官(OAR s)受量的差异。结果 3D-CRT及IMRT的靶区适形度指数(C I)、均匀性指数(H I)均较CRT计划好,同时减少了脑干、腮腺的受照射剂量;3D-CRT及IMRT的处方剂量覆盖靶区体积百分比高于CRT。结论对鼻腔NK/T细胞淋巴瘤,3D-CRT及IMRT可以提高靶区的适形度和均匀度,在保护脑干、腮腺方面较CRT具有明显优势,其中IMRT优势更明显。
Objective To compare the dosimetry difference of three radiation therapies for patients with nasal NK/T cell lymphoma.Methods Six patients with nasal NK/T cell lymphoma were treated by conventional radiation therapy（CRT）,three dimensional conformal radiation therapy（3D-CRT） and intensity modulated radiation therapy（IMRT） in the same treatment planning system（TPS）.The referring point should reach prescription dose（54Gy） in CRT,and the planning target volume（PTV） reach 95% of the prescription dose（54Gy） in 3D-CRT and IMRT.The difference of irradiation dose between target volume and organ at risk was compared by isodose curve and dose volume histogram（DVH）.Results The conformity index（CI） and heterogeneity index（HI） of 3D-CRT and IMRT were better than CRT.3D-CRT and IMRT could reduce the exposure dose of brain stem and parotid gland.The coverage volume percentage of prescription doses of 3D-CRT and IMRT were better than CRT.Conclusion 3D-CRT and IMRT can increase the dose conformity and homogeneity index,and they can protect brain stem,parotid gland much better than CRT for patients with nasal NK/T cell lymphoma.IMRT has more apparently advantage.
出处
《临床肿瘤学杂志》
CAS
2011年第7期644-647,共4页
Chinese Clinical Oncology
关键词
NK/T细胞淋巴瘤
三维适形放疗
调强适形放疗
放射治疗
剂量学
NK/T cell lymphoma
Three dimensional conformal radiation therapy
Intensity modulated radiation therapy
Radiotherapy
Dosimetry
