摘要
正常肠黏膜屏障由机械屏障、化学屏障、免疫屏障、生物屏障构成,能有效阻止肠道内细菌和内毒素易位。检测肠黏膜通透性可反映肠黏膜屏障功能。肠黏膜屏障受营养、感染、损伤等多种因素影响。研究表明肠黏膜屏障功能损伤与炎症性肠病(IBD)密切相关,然而其为IBD的病因还是继发性改变目前仍存在争议。保护和恢复肠黏膜屏障功能对IBD的治疗具有重要意义。
Intestinal mucosal barrier is mainly composed of mechanical barrier, chemical barrier, immunologic barrier and biologic barrier, which can prevent luminal bacteria and endotoxin from translocating into systemic circulation. Intestinal permeability is usually used to evaluate the function of intestinal mucosal barrier. Changes of intestinal mucosal barrier are associated with many factors such as nutrition, infection and injury. Studies showed that the impaired barrier function was closely related to inflammatory bowel disease （IBD）, but whether it is a primary event in IBD or a phenomenon secondary to the intestinal inflammation is still a controversial issue. Protection and restoration of barrier function may be a promising therapeutic strategy for IBD.
出处
《胃肠病学》
2011年第6期379-381,共3页
Chinese Journal of Gastroenterology
关键词
炎症性肠病
肠黏膜屏障
上皮细胞
通透性
紧密连接部
Inflammatory Bowel Disease
Intestinal Mucosal Barrier
Epithelial Cells
Permeability
Tight Junctions
