摘要
目的:探讨谷氨酰胺(Gln)防治电离辐射损伤肠道的作用机制。方法:用137Cs作为放射源,以4Gy的剂量对小鼠进行一次性全身照射,观察Gln对肠道辐射损伤的保护作用。结果:辐射小鼠小肠粘膜中丙二醛(MDA)含量升高,超氧化物歧化酶(SOD)活性、还原型谷胱甘肽(GSH)含量、蛋白质和DNA含量下降,小肠绒毛高度降低,隐窝深度变浅,小肠壁全层厚度和绒毛表面积减小。补充Gln对上述指标的改变有抑制作用,分别达到或接近正常组水平。结论:Gln对肠道的辐射损伤有保护作用。
Objective: To study the protective effect of glutamine on intestine in mice damaged by radiation. Methods: Mice were exposed to 137 Cs rays (dose of 4Gy) with the whole body. The protetive effects of glutamine on intestine radiational damages were studied. Result: After radiation, GSH contents, SOD activities, protein and DNA contents were decreased and MDA contents were increased in intestinal mucosa. Villus height was shortened, crypt depth was deepened, wall width and villus surface area were decreased. Glutamine supplement restrained the changes of indices above mentioned and made them close to normal levels. Conclusion: Glutamine supplement had the protective effect on radiation damage in mice.
出处
《营养学报》
CAS
CSCD
北大核心
2004年第6期426-429,共4页
Acta Nutrimenta Sinica
关键词
谷氨酰胺
辐射
肠道
glutamine
radiation
intestine
