摘要
目的观察急性逆行胃电刺激（RGES）对肥胖患者胃容受性、胃排空和胃肠激素释放的影响。方法选取肥胖患者16例。第1天经胃镜放置胃黏膜电极，第2天进行液体餐负荷试验、标准固体餐胃排空试验，每次试验开始前30min及试验过程中给予RGES。标准固体餐胃排空试验前后检测血清瘦素、生长激素释放肽、抵抗素和肽YY。第3天给予假性刺激，通过自身对照比较急性RGES对相关指标的影响。结果16例患者体重指数为（32.90士2．99）kg／m^2。急性RGES明显减少患者达到饱感所进液体餐量[分别为（460土148）ml和（630±219）ml，t=7．200，P〈0．01和最大耐受程度进餐量[分别为（699士215）ml和（926士295）ml，t=-5．390，P〈0．01]，对标准固体餐胃半排空时间、1h及2h标准固体餐存留率的影响分别为（109士26）min和（103士31）min，t=1．009，P=0．329；（63．37±9．75）％和（59．73士12．87）％，t=1．834，P=0．087；（42．22±13．97）％和（38．33±16．87）％，t=1．780，P=0．095。急性RGES后胃肠激素水平／刺激前水平和假性胃电刺激后水平／刺激前水平分别为瘦素（1．03±0．34和1．08±0．38，t=．386，P=0．705）、生长激素释放肽（0．99±0．11和0．98±0．12，t=0．413，P=0．685）、抵抗素（1．11士0．25和0．99士0．24，t=1．753，P=0．100）、肽YY（1．56±0．71和1．33士0．61，t=1．402，P=0．181）。结论急性RGES通过降低胃容受性显著减少肥胖患者的进食液体餐量，一定程度上减缓胃排空，但对相关胃肠激素释放无显著影响。
Objective To observe the effect of acute retrograde gastric electrical stimulation （RGES） on gastric accommodation, emptying and gastrointestinal hormones releasing in obese patients. Methods Sixteen obese patients were examined. On the first day, a pair of mucosal gastric electrodes was placed under endoscope. The liquid meal load test and the standard solid meal gastric emptying test were carried out on the second day. RGES was performed starting at 30 minutes before each test and through the whole testing process. The serum leptin, ghrelin, resistin and peptide YY were examined before and after the standard solid meal gastric emptying test. On the third day, sham stimulation was given. The effect of acute RGES on related index was compared by self-control. Results BMI of the 16 patients was （32.90±2.99） kg/m^2. Acute RGES significantly reduced theliquid meal volume of fullness [（460±148） ml and （630±219） ml, t=-7. 200, P〈0.01] and the maximal tolerable meal volume [（699±215） ml and （926±295） ml, t=-5. 390, P〈0.01]. The effects of RGES and sham RGES on half-emptying time of standard solid meal was （109±26） rain and （103±31） min （t=l. 009, P=0. 329）; on the retention rate of standard solid meal at one hour and two hour was （63.37±9.75）; and （59.73±12.87）% （t=l. 834, P=0. 087）, （42.22±13.97）% and （38.3±16.87）% （t= t. 780, P=0. 095）, respectively. The ratio of gastrointestinal hormones after and before the stimulation also of the sham stimulation, leptin was 1.03±0.34 and 1.08±0.38 （t=-0. 386, P=0. 705）, ghrelin was 0. 99±0.11 and 0.98±0.12 （t=0. 413, P=0. 685）, resistin was 1.11±0. 25 and 0.99±0.24 （t=l. 753, P=0. 100）, and peptide YY was 1.56±0.71 and 1.33± 0.61 （t= 1. 402, P= 0. 181）. Conclusions In obese patients, acute RGES significantly reduce the liquid meal volume by lower gastric accommodation, to certain extent which will delay gastric emptying. There is no significant influence on gastrointestinal hormones releasing.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2011年第6期387-391,共5页
Chinese Journal of Digestion
基金
国家自然科学基金面上项目（81070299）
首都医学发展科研基金重点支持项目（2009-2018）
关键词
电生理学
胃
电刺激
肥胖症
进食
胃排空
胃肠激素类
Electrophyciology
Stomach
Electric stimulation
Obesity
Eating
Gastric emptying
Gastrointestinal hormones
