摘要
目的:观察抗纤软肝冲剂对肝纤维化的预防作用并探讨其机理。方法:采用四氯化碳、高脂、高胆固醇、低蛋白等复合因素制造肝纤维化模型,同时用抗纤软肝冲剂治疗,观察其对肝纤维化指标的影响,以秋水仙碱作为对照,结果:抗纤软肝冲剂对肝纤维化大鼠有升高白蛋白(Alb),降低谷丙转氨酶(ALT)和球蛋白(G)的作用;可调整机体免疫功能,降低血清免疫复合物(IC);具有显著降低血清透明质酸(HA)、层粘蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、肝脏羟脯氨酸(Hyp)的作用;可以改善肝脏病理,抑制纤维化形成。结论:抗纤软肝冲剂具有确切的预防肝纤维化的作用。
Aim:To study the effect of Kangxian Ruangan granule on experimental hepatic fibrosis in Rats. Method: Wistar rats models with the hepatic fibrosis were induced by complex factors of which carbon tetrachloride was the most impor tant and meanwhile protected with Kangxian Ruangan granule or Colchieine as control group. The indexes of hepatic fibrosis were assayed. Result: Kangxian Ruangan granule raised the serum level of Alb. decreased the serum level of globin and ALT; the level of serum CIC、 HA、LN, PC 333333 、Ⅳ-C and Hyp in liver tissue were significantly lower than those of the model group;the proliferation degree of collagenous fibers was also lower than that of the model group. Conclusion: Kangxian Ruangan granule shows definite protective and therapeutic effect on experimental hepatic fibrosis model rat.
出处
《中西医结合肝病杂志》
CAS
1999年第6期26-28,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
湖北省教委资助项目(No.96A027)
关键词
动物实验
肝硬化
中医药疗法
抗纤软肝冲剂
Experimental Hepatic Cirrhosis Therapy of Traditional Chinese Medicine Experiment on Animals Kangxian Ruangan Granule
