摘要
目的： 比较利培酮与舒必利对精神分裂症的临床疗效及对各症状群的作用特点， 观察其副作用。 方法： 将符合入组标准的精神分裂症患者随机分为利培酮与舒必利两组，用阳性与阴性症状量表 （ＰＡＮＳＳ）、简明精神病评定量表 （ＢＰＲＳ）、临床疗效总评 （ＣＧＩ）、阴性症状量表 （ＳＡＮＳ） 和副反应量表（ＴＥＳＳ） 等评定其疗效和副反应。 结果： 利培酮组疗效优于舒必利组， 对阴性症状的效果更显著。ＴＥＳＳ总分两组间差异无显著性。 结论： 利培酮对精神分裂症的疗效优于舒必利， 对阴性症状效果更为突出。
Objective:To study the efficacy and side effect of risperidone and sulpiride in the treatment of schizophrenia. Method:Patients with diagnosis of schizophrenia and fulfilling the admission criteria to the study were randomly assigned to two groups that were treated with either risperidone or sulpiride. The therapeutic response and side effects were evaluated with the PANSS, SANS, BPRS, CGI and TESS. Results:The overall therapeutic effect of risperidone were superior to that of sulpiride with significant difference as measured with the PANSS, SANS and CGI. However, there was on statistical difference in the TESS score between the two groups. Conclusion:Risperidone is superior than sulpiride in the treatment of schizophrenia,especially the negative symptoms.
出处
《临床精神医学杂志》
1999年第6期331-333,共3页
Journal of Clinical Psychiatry
