摘要
目的:考察2种盐酸特比萘芬乳膏体外透过皮肤量及其在皮肤中贮药量以阐明其起效途径。方法:采用改良Franz扩散池,离体小型猪皮肤,取2种盐酸特比萘芬乳膏(国产与进口制剂)各1.0g进行体外透皮扩散试验,以反相高效液相色谱法测定接受液中盐酸特比萘芬的含量(计算透过率)和皮肤中贮药量。结果:国产及进口制剂中盐酸特比萘芬的体外皮肤透过率均低于0.05%,皮肤贮药量分别为(43.1±7.5)、(42.2±4.9)μg·cm-(2n=6)。结论:2种制剂中盐酸特比萘芬几乎不透过皮肤,皮肤贮药量相近,表明二者药效和安全性基本一致,并主要发挥局部治疗作用。
OBJECTIVE： To investigate the transdermal amount and dermal loading quantity of 2 kinds of Terbinafine hydrochloride （TH） cream to interpret the acting approach. METHODS： 2 kinds of TH cream （domestic and imported preparations） 1.0 g were used for in vitro transdermal diffusion test of miniature pigs skin using modified Franz diffusion cell. TH concentration in re- ceiving solution and dermal loading quantity of TH were determined by RP-HPLC. RESULTS： The transdermal amounts of TH in domestic and imported preparations were below 0.05% and the dermal loading quantities were （43.1 ± 7.5） μg. cm-2 and （42.2 ± 4.9） μg.cm-2 （n=6）, respectively. CONCLUSION： 2 kinds of TH cream hardly pass through derma, and dermal loading quantites of TH are similar between them. It indicates that efficacy and safety of the 2 kinds of cream are in substantial agreement and they mainly play region effect.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第29期2723-2725,共3页
China Pharmacy
基金
广州市重大科技专项计划(2008A1-E4101-4)
关键词
盐酸特比萘芬乳膏
体外透皮扩散试验
皮肤贮药量
Terbinafine hydrochloride cream
Transdermal diffusion experiment
Dermal loading quantity
