摘要
目的:优化白芷中药材有效成分的提取工艺;全面系统地考察与研究市场上白芷中药材的质量。方法:以白芷中欧前胡素和异欧前胡素的含量为指标,采用高效液相色谱法测定,利用正交试验,对渗漉法提取白芷有效成分的工艺条件进行优选;按照《中国药典》2005年版一部白芷项下[含量测定]方法检验了62批次市场上销售的白芷药材中香豆素类物质的含量。结果:乙醇渗漉提取法:药材浸泡24h,加80%乙醇8倍量渗漉,欧前胡素和异欧前胡素的平均提取率为78%;市场上销售的白芷药材中香豆素类物质的含量符合药典的要求。结论:应用渗漉法工艺提取白芷中药材有效成分效率高,稳定性好,适合工业化生产;目前市场上流通的白芷中药材的质量可靠。
Objective： To optimize the conditions for extracting effective components of Chinese herbal medicine Angelica dahurica;to investigate and research on the quality of market herbal Angelica dahurica comprehensively and systematically.Methods： Taking the content of imperatorin and iso imperatori for index,detect the effective components of angelica dahurica by high-performance liquid chromatography（HPLC）;using the orthogonal experiment,optimize the permeability technology conditions and extract the effec-tive ingredients of angelica dahurica;According to China pharmacopoeia 2005 version of angelica dahurica captioned [the content deter-mination] method,test the content of kind material coumarin of 62 batch market medicinal angelica dahurica.Results： Ethanol permeabil-ity extraction： 24h,80% medicinal soaking ethanol 8 times,the average extraction rate of imperatorin and iso impera-tori is 78%;the content of coumarin in market medicinal Angelica dahurica conform to the pharmacopoeia requirements.Conclusion： The application of permeability method extracting effective components of Angelica dahurica process of high efficiency,good stability,suitable for industrial production;the quality of current market medicinal Angelica dahurica is reliable.
出处
《现代生物医学进展》
CAS
2011年第14期2759-2766,2774,共9页
Progress in Modern Biomedicine
关键词
白芷
中药材
欧前胡素
提取工艺
药材质量
Angelica dahurica
Chinese herbal medicine
Imperatorin
Extraction process
Medicinal material quality
