摘要
目的探讨联合检测血清瘦素及促绒毛膜性腺激素(β-hCG)对早期自然流产发生的诊断价值。方法用ELISA法测定73名自然流产患者、83名正常妊娠者及50名未孕健康妇女血清瘦素及β-hCG水平。结果妊娠早期正常妊娠者血清瘦素、β-hCG水平高于自然流产患者和非妊娠者,差异显著(P<0·05);非妊娠组瘦素、β-hCG水平低于自然流产组,差异显著(P<0·05)。妊娠早期以血清瘦素≤824·2ng/ml,β-hCG≤4268·0mIU/ml为预测界值,诊断自然流产的敏感度、特异度和阳性率分别为71·2%、92·5%和95·6%。结论 妊娠早期,联合检测孕妇血瘦素及β-hCG可进一步提高对自然流产发生的诊断准确率,具有重要的临床意义。
Objective To investigate the value of maternal serum levels of leptin and beta-human chorionic gonadotropin （β-hCG） on early pregnancy who will suffer spontaneous abortion.Methods ELSIA were used to measure the serum leptin and β-hCG levels in 73 spontaneous abortion women,83 normal pregnancy and 50 normal nonpregnancy women.Results The levels of serum leptin and β-hCG in normal pregnant women were significantly higher than those in pregnancies that subsequently developed spontaneous abortion and non-pregnant women（P0.05）.Meanwhile,the levels of serum leptin and β-hCG in non-pregnant group were lower than those in spontaneous abortion group（P0.05）.Combining the cutoff concentration of leptin was 824.2 ng/ml and β-hCG was 4268.0 mIU/ml in early pregnancy,the sensitivity was 71.2%,specificity was 92.5%,positive predictive value was 95.6%.Conclusion The combination of leptin and β-hCG can improve diagnostic of accuracy spontaneous abortion in early pregnancy.
出处
《中外医学研究》
2011年第20期49-50,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
瘦素
自然流产
Β-人绒毛膜促性腺激素
Leptin
Spontaneous abortion
Human chorionic gonadotropin （β-hCG）
