摘要
目的分析假丝酵母菌菌血症的高危因素、临床表现、菌群分布和临床诊治。方法对2008年3月-2010年5月血培养确诊为假丝酵母菌菌血症的19例患者临床资料进行回顾分析。结果 84.2%的假丝酵母菌菌血症患者有≥3种基础疾病,100.0%患者有≥4个高危因素,94.7%患者有静脉导管留置,63.2%患者为导管相关性感染;以发热、白细胞和中性粒细胞升高、各脏器功能不全为主要表现,白色假丝酵母菌、光滑假丝酵母菌、热带假丝酵母菌、近平滑假丝酵母菌、克柔假丝酵母菌分别占47.4%、15.8%、15.8%、15.8%、5.2%,治疗措施包括拔除深静脉导管和给予抗真菌药物,治愈率为63.2%。结论假丝酵母菌菌血症多发生于有多个基础疾病和多个高危因素者,以白色假丝酵母菌较为多见。
OBJECTIVE To analyze the risk factors, clinical manifestation and flora distribution of candidemia and provide a reference for clinical diagnosis and therapy. METHODS Totally 19 cases of candidemia in our hospital were analyzed retrospectively from Mar 2008 to May 2010. RESULTS 84.2% of patients with candidemia suffered from three or more, underlying diseases. All of the patients with candidemia had four or more high risk factors. 94.7% of patients with candidemia were placed catheter and 63.2% of patients with candidemia were confirmed CRBSI. Of these clinical manifestations , fever, elevated white cells and neutrophils, failure of liver, kidney and circulation and MODS were the main manifestations. The distribution of isolated Candida species were Candida albicans （47.4%）, Candida glabrata （15.8%）, Candida tropicalis （15.8%）, Candida para psilosis （15.8%） and Candida krusei （5.2%）. Therapeutic measure included removing catheters and using antifungal agents. The cure rate of patients with candidemia was 63. 2%. CONCLUSION Candidemia usually occurs in patients who suffered from multiple underlying diseases and with high risk factors, of which Candida albicans is the most common pathogen.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第14期2957-2959,共3页
Chinese Journal of Nosocomiology
