摘要
目的了解医院内侵袭性真菌感染的发病率和菌种分布特点,为减少真菌感染提供依据。方法对3年间住院患者真菌培养阳性的病例进行了分析,从患者年龄、疾病种类、标本、菌种分布、科室等方面进行了分析研究。结果医院内侵袭性真菌感染的发病率为4.32%,患者年龄在7～96岁,以男性老年患者最多,均患有基础疾病;感染部位以下呼吸道最多,其次为泌尿道、消化道;检出的真菌种类以假丝酵母菌属为主,约占93.38%;且白色假丝酵母菌居多,占66.19%,丝状真菌占6.62%。结论白色假丝酵母菌仍是医院内侵袭性真菌感染的主要病原菌;侵袭性真菌感染的流行病学正在发生改变,非白色假丝酵母菌和曲霉菌属引起的感染正在逐年增加。
OBJECTIVE To investigate the current status, the clinical features and the pathogens of invasive fungal infections in hospital in order to provide clinical treatment based on identification and susceptibility test. MIETHODS The fungus-cultured positive cases among the discharged patients from Jan 2004 to Nov 2006, were analyzed according to their definite diagnosis of invasive fungal infections under the items, such as the patients age, underlying disease, sample, strain, and species distribution. RESULTS The rates of invasive fungal infections were 4.26%. There were 2221 fungus strains belonged to 8 species in all samples; the patients age was 7-96 years with 2 kinds of various underlying diseases; the age of 2221 cases was 60 years old, mainly senile patients with various diseases accounted for 68. 29 %. Lower respiratory tract was the most frequent infection site. The main pathogens of invasive fungal infections were Candida spp （93.38 %）. Strains of Candida albicans were the most frequent organism isolated accounted for 66.19 % of all the isolates. C. glabrata, C.krusei and C. tropica lis accounted for 9.19%, 8. 10% and 4. 50%, respectively, the others accounted for only 6.32%. The main infected sites were lower respirtory tract, urinary tract and digestive tract. CONCLUSIONS Candida spp are still the main pathogens of invasive fungal infections. The epidemiological properties of invasive fungal infections is changed. The incidence of non-C, albicans and the Aspergillus strains that arouse invasive infections is increasing recently.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第7期1030-1033,共4页
Chinese Journal of Nosocomiology
基金
山西省高校科技研究开发项目(2006213)
关键词
侵袭性真菌感染
病原菌
流行病学
Invasive fungal infections
Pathogens
Epidemiology
