摘要
目的:研究β-环糊精(β-CD)包合中药复方愈溃胶囊中挥发油的最佳工艺。方法:采用饱和水溶液法制备包合物,通过正交试验设计对包合工艺条件进行优选,并采用差示量热扫描法、热重分析法和红外光谱法对包合物进行表征。结果:最佳包合工艺条件是挥发油(mL)-β-CD(g)1∶10,包合温度50℃,包合时间2 h,表征分析显示挥发油被β-CD成功包合。结论:优选的包合工艺操作简便、工艺稳定、挥发油包合率和包合物得率较高。
Objective：To obtain the optimized inclusion technology of volatile oil from Yukui capsule with β-cyclodextrin（β-CD）.Method： The inclusion compound was prepared by saturated peroxide solution method and characterized by differential scanning calorimetry,thermogravimetric analysis and infrared spectrometer.Orthogonal design was applied to optimize preparation conditions.Result： The optimum conditions for inclusion process were as follows： the ratio of volatile oil（mL） to β-CD（g） was 1∶10,the inclusion temperature was 50 ℃ and clathration time was 2 h.The inclusion technique was successful,which had been verified by characterizing structure.Conclusion： The developed inclusion process is simple,stable and reliable,with a high inclusion rate and a high yield of inclusion compound.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第14期19-22,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中国科学院西部行动计划高新技术项目(KGCX2-SW-508)
关键词
当归
桂枝
挥发油
Β-环糊精包合
Angelica Sinensis Radix
Cinnamomi Ramulus
volatile oil
β-cyclodextrin inclusion
