期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IL-21在Th17细胞炎症反应中的作用 被引量：5

Effects of IL-21 in Th17 cell maintenance
原文传递
导出
摘要 Th17细胞是新近发现的T淋巴细胞亚群。作为不同于Th1、Th2的细胞亚群，已经被证实在自身免疫病、感染、炎症等疾病中发挥重要作用。IL-21作为Th17细胞的自分泌调节因子，在Th17细胞功能的维持、抑制Th1、调节性T细胞（Treg）分化等方面发挥关键作用。Th17细胞能够自分泌产生IL-21，从而促进自身分化过程。IL-21在Th17细胞维持中的作用及潜在机制的揭示，必将为Th17细胞致病机制的探索提供新思路。 Th17 cell has recently been identified as an IL-17-producing CD4^＋ Th cell, and its functions and regulatory mechanisms in immune responses have been studied extensively. Functional studies have provided evidence that Th17 cells are important for the modulation of autoimmune responses and inflammation. Murine Th17 cell differentiation is promoted by the coordinated functions of distinct cytokines including TGFβ, IL-6,IL-21 and IL-23, whereas IL-2,IL-4,IFNγ and IL-27 inhibit Th17 ceil differentiation. Th17 cell could produce IL-21 ,thus promotes auto-differentiation. IL-21 is the new target in Th17 cell-mediated diseases.
作者 刘巍 田文单 Sally A.Huber
机构地区 哈尔滨医科大学附属第一医院心内科 Burlington
出处 《国际免疫学杂志》 CAS 北大核心 2011年第4期274-276,共3页 International Journal of Immunology
基金 国家自然科学基金青年基金（30800481）
关键词 TH17细胞 IL-21 TGF-Β Th17 cell IL-21 TGF-β
分类号 R3 [医药卫生—基础医学]
  • 相关文献

参考文献18

  • 1刘巍,李为民,Huber SA.白细胞介素-21的免疫调节机制[J].国际免疫学杂志,2010,33(4):265-268. 被引量：2
  • 2Sarra M, Pallone F, Macdonald TT, et al. Targeting interleukin-21 in immune-mediated pathologies. Curt Drug Targets, 2010, 11 (5) : 645-649.
  • 3Review. Wei L. Immunological aspect of cardiac remodeling: T lymphocyte subsets in inflammation-mediated cardiac fibrosis. Exp Mol Pathol, 2010,90( 1 ) :74-78. [ Epub ahead of print].
  • 4Galicia G, Kasran A, Uyttenhove C, et al. ICOS deficiency re- suits in exacerbated IL-17 mediated experimental autoimmune en- cephalomyelitis. J Clin Immunol, 2009, 29(4): 426-433.
  • 5郑钰涵,吴晓东,孙兵.Th17细胞分化和功能的研究进展[J].生命科学,2010,22(6):534-538. 被引量：25
  • 6Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell trilogy. Curr Opin Immunol, 2007,19 ( 6 ) : 652- 657.
  • 7Sutton CE, Lalor SJ, Sweeney CM, et al. Interleukin-I and IL-23 induce innate IL-17 production from gammadelta T cells, amplif- ying Thl 7 responses and autoimmunity. Immunity, 2009, 31 (2) : 331-341.
  • 8Mix E, Meyer-Rienecker H, Hartung HP, et al. Animal models of multiple sclerosis--potentials and limitations. Prog Neurobiol, 2010, 92(3) : 386-404.
  • 9Veldhoen M, Hocking R J, Flavell RA, et al. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomye- litis, but chronic inflammation is needed to sustain disease. Nat Immunol, 2006, 7(11): 1151-1156.
  • 10Hu Y, Shen F, Crellin NK, et al. The IL-17 pathway as a major therapeutic target in autoimmune diseases. Ann N Y Acad Sei, 2010 Dec 13. [ Epub ahead of print].

二级参考文献48

  • 1Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol, 1986, 136:2348-57.
  • 2Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol, 2007, 25:221-42.
  • 3Murphy CA, Langrish CL, Chen Y, et al. Divergent proand antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med, 2003, 198:1951-7.
  • 4Cua DJ, Sherlock J, Chen Y, et al. Interleuldn-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature, 2003, 421:744-8.
  • 5Aggarwal S, Ghilardi N, Xie MH, et al., Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem, 2003, 278:1910.
  • 6Langrish CL, Chert Y, Blumenschein WM, et al., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med, 2005, 201:33.
  • 7Komiyama Y, Nakae S, Matsuki T, et al. IL-17 plays an important role in the development of experimental autoimmane encephalomyelitis. J Immunol, 2006, 177:566-73.
  • 8Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 2006, 441:235-8.
  • 9Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-β induces development of the T(H)17 lineage. Nature, 2006, 441:231-4.
  • 10Veldhoen M, Hocking RJ, Atkins C J, et al. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity, 2006, 24:179-89.

共引文献25

同被引文献81

  • 1Young DA, Lowe LD, Booth SS, et al. IL-4, IL-10, IL-13 and TGF-beta from an altered peptide ligand-specifie Th2 cell clone down-regulate adoptive transfer of experimental autoimmune en- cephalomyelitis: Immunol, 2000 ; 164 (7) : 3563-3572.
  • 2Shimizu Y, Ota K, Kubo S, et al. Association of Thl/Th2-related chemokine receptors in peripheral T cells with disease activity in patients with muhiple sclerosis and neuromyelitis optica. Eur Neurol, 2011 ;66(2) : 91-97.
  • 3Jianguo Liu , Shanjin Cao , Lisa M. Herman et al. Differential Regulation of Interleukin (IL) -12 p35 and p40 Gene Expression and Interferon (IFN)-~/-primed IL-12 Production by IFN Regulatory Factor 1. JEM, 2003. 198(8) : 1265-1276.
  • 4Mangan PR, Harrington LE, O' Quinn DB et al. Transforming growth factor-beta induces development of the T(H) 17 lineage. Nature,2006; 441(7090) : 231-234.
  • 5Lee YK, Turner H. Maynard CL, et al. Late developmental plasticity in the T helper 17 Lineage. Immunity, 2009; 30( 1 ) : 92- 107 .
  • 6Sutton C, Brereton C, Keogh B, et al. A crucial role for interleu- kin (IL) -1 in the induction of IL-17-produeing T cells that medi- ate autoimmune encephalomyelitis. Exp Med , 2006 ; 203 ( 7 ) : 1685-1691.
  • 7Fletcher JM, Lalor SJ, Sweeney CM, et al. T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clinical and Experimental Immunology, 2010 ; 162 ( 1 ) : 1-11.
  • 8Yang L, Anderson DE, Baecher-Allan C et al. IL-21 and TGF- beta are required for differentiation of human T(H) 17 ceils. Nature, 2008; 454(7202) : 350-352.
  • 9Manel N, Unutmaz D, Littman DR. The differentiation of human T( H )-17 ceils requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol, 2008; 9(6) : 641-649.
  • 10Wilson NJ, Boniface K, Chan JR et al. Development, cytokine profile and function of human interleukin 17-producing helper T ceils. Nat Immunol, 2007; 8(9) : 950-957.

引证文献5

二级引证文献20

国际免疫学杂志
2011年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部