摘要
胸腺是哺乳动物重要的中枢免疫器官,是决定和制约免疫系统老化的关键。胸腺作为T细胞分化、发育、成熟重要场所,随着增龄表现出明显萎缩的现象进而影响到T细胞的发育、增殖和输出,从而造成外周淋巴组织中T细胞的质与量的异常,这样就不可避免地降低了免疫系统对外来的抗原应答性,导致病原体清除延迟,增加了老年人罹患癌症、自身免疫性疾病以及病毒、细菌等病原感染的风险,了解胸腺增龄性萎缩过程中转录因子、细胞因子的作用及增龄性萎缩胸腺功能恢复调节研究概况很有必要。
The thymus is the most important central immune organ of mammals which determines the aging of immune system.It is the major site of T cell maturation where extensive proliferation and differentiation occur.Age-related deterioration of the thymus can affect the function of peripheral T ceils,which inevitably impairs the responsiveness of immune system to foreign antigens,leading to delayed clearance of pathogens.This also increases the risk of elderly people suffering from cancer,autoimmune diseases and infections diseases caused by viruses,bacteria and other pathogens.This review presents the latest information on the role of transcription factors and cytokines in the progress of age-related thymic involution.We also review the studies on the regulation of the functional recovery of thymus.
作者
王长山
李丽
朱喜科
WANG Chang-shan;LI li;ZHU Xi-ke(Research Center for Medicine,China Medical Universiry the Shenging Hopital,Shenyang 110004,China)
出处
《国际免疫学杂志》
CAS
北大核心
2011年第4期257-261,共5页
International Journal of Immunology
基金
国家自然基金资助项目(30872715)
辽宁省自然科学基金项目(20082082)
关键词
胸腺增龄性萎缩
胸腺微环境
细胞因子
分子机制
Age-related thymic involution
Thymie microenvironnlent
Cytokines
Molecular mechanism
