摘要
目的:本文通过分析胸腺的中枢耐受和退化,探讨胸腺保护与机体抗衰老的关系。资料来源:应用计算机检索美国NCBIPubmed数据库1980-01/2004-02关于胸腺保护和机体抗衰老的文章,主要检索主题词包括“thymus,toler-ance,involution,aging”,语言设为英语。资料选择:选取报道胸腺细胞表达自身抗原、胸腺细胞凋亡和退化影响因素的原创实验性文章以及2001年以来权威期刊关于胸腺中枢耐受和衰老的相关综述文章。纳入标准:①具有原创性,论点论据可靠的实验文章。②观点明确,分析全面的综述文章。③文献主体内容与本课题联系紧密的文章。排除标准:具有明显实验设计和结果错误的文章及观点模糊的综述。质量评价主要考察资料的真实性、实施过程是否严密。资料提炼:共检索到关于胸腺保护和机体抗衰老的文献40篇,25篇文献符合纳入标准。排除的15篇文献均为重复性文章。资料综合:25篇文献分别阐明了中枢耐受、机体衰老和胸腺退化的影响因素问题。胸腺执行着重要的T细胞中枢耐受。该耐受过程伴随着动态的正负选择,正选择保持抗原特异性T细胞输出。保护胸腺是目前惟一能够维持输出抗原特异性T细胞的手段。保护胸腺的前提是从根本上了解胸腺退化的具体影响因素。结论:胸腺表达了几乎所有外周自身抗原,不但可以维持免疫系统特异性T细胞的输出,同时对避免自身免疫疾病及免疫缺陷病有着重要的意义。物理化学、激素、疾病、药物和年龄等因素引起的胸腺退化过程往往伴随者正负选择平衡的打破。胸腺衰老即指示人体衰老,保护胸腺实际上就是一种抗衰老策略。
OBJECTIVE: To investigate the association between thymus protection and anti-aging through analyzing thymic central tolerance and degeneration. DATA SOURCES: An online search of American NCBI Pubmed database was undertaken to identify English articles about thymus protection and anti-aging published between January 1980 and February 2004 by using the of 'thymus, tolerance, involution, aging'. STUDY SELECTION: The original experimental articles, which reported self-antigens expressed by thymocytes, the influencing factors of thymocyte apoptosis and degeneration, were selected, and the reviews about thymus tolerance and aging in authorized journals since 2001 were selected. Inclusion criteria: ①Origin and reliable experimental articles; ②Well analyzed review articles with clear opinions; ③Articles with close relationship with the topic in this paper. Exclusion criteria: Articles with obvious errors in the experimental design or results and reviews with obscure opinions. Quality evaluation mainly inspected the validity of data and whether the experimental duration was accurate or not. DATA EXTRACTION: Totally 40 articles about thymus protection and anti-aging were collected, and 25 were in accordance with the inclusion criteria, the 15 excluded ones were repetitive. DATA SYNTHESIS: The 25 articles elucidated central tolerance, aging and influencing factors of thymus degeneration, respectively. Thymus performed important T cell central tolerance. This tolerance duration was accompanied by dynamic positive and negative selections, and positive selection kept the output of antigen specific T cells, which could be maintained only by the protection of thymus. The premise of thymus protection is to basically understand the specific influencing factors for the degeneration of thymus. CONCLUSION: Thymus can express nearly all the peripheral self-antigens. It can not only maintain the output of specific T cells in immune system, but also play an important role in avoiding autoimmune disease and immune deficiency. The process of thymus degeneration caused by the factors of physics, chemistry, hormone, disease, medicine and age is always followed by the out-of-balance of positive and negative selection. Thymus aging stands for aging of human body, thymus protection is actually an anti-aging strategy.
出处
《中国临床康复》
CAS
CSCD
北大核心
2005年第23期164-166,共3页
Chinese Journal of Clinical Rehabilitation
基金
国家高科技研究发展计划(2001AA215131)
广东省自然科学基金项目(04300653)
暨南大学引进优秀人才科研启动基金(51204066)~~
