期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

定量蛋白质组学在系统性红斑狼疮疾病中的应用 被引量：1

Quantitative proteomics＇ Application in disease of systemic lupus erythematosus
原文传递
导出
摘要 定量蛋白质组学的目的是对复杂的混合体系中所有的蛋白质进行鉴定，并对蛋白质量的变化进行测定，是当前生物科学研究中的重要内容。近年来，以质谱为基础的定量蛋白质组学技术在分析蛋白质组或亚蛋白质组方面取得令人瞩目的成就。对寻找和发现疾病中的特异标记物，对疾病的预防、诊断及疗效的监测方面具有重要作用。当前定量蛋白质组学在系统性红斑狼疮SLE中的应用有了长足的发展。 Quantitative proteomics is aimed to identify all the proteins in a complex mixed system, and to quantify the changes of the proteins In recent years, based on mass spectrometry , made remarkable achievement was in analysis of proteins or sub-group proteins. These technologies play important roles in search for specific disease markers and for disease prevention, diagnosis and treatment. In this paper, we reviewed the current development and the application in systemic lupus erythematosus（SLE） of the quantitative proteomics.
作者 眭维国 汤冬娥 戴勇
机构地区 中国人民解放军第 广西师范大学生命科学学院
出处 《国际免疫学杂志》 CAS 北大核心 2011年第4期245-247,261,共4页 International Journal of Immunology
基金 国家自然科学基金资助项目（30872378）
关键词 定量蛋白质组学 系统性红斑狼疮 应用 Quantitative proteomics Systemic lupus erythematosus Application
分类号 R593 [医药卫生—内科学]
  • 相关文献

参考文献23

  • 1Ma Z, Liu C, Deng B, et al. Different protein profile in amniotic fluid with nervous system malformations by surface-enhanced laser desorption-ion-ization/time-of-flight mass spectrometry (SELDI- TOF-MS ) technology. 20bstet Gynaecol Res, 2010 , 36 (6) : 1195-1203.
  • 2Kafka AP, Kleffmann T, Rades T, et al. The application of MAD- LI TOF MS in biopharmaceutical research, Int J Pharm, 2010 , 10: [Epub ahead of print].
  • 3Grosvenor A J, Morton JD, Dyer JM. Isobaric Labeling Approach to the Tracking and Relative Qaaatitation of Peptide Damage at the Primary Structural Level. J Agrie Food Chem, 2010 ,58(24) : 12672-12677.
  • 4Suzuki M, Ross GF, Wicrs K, et al. Identification of a urinary proteomie signature for lupus nephritis in children. Pediatr Neph- rol, 2007, 22(12) :2047-2057.
  • 5Mann M. Quantitative proteomies? Nat Bioteehnol, 1999, 17 (10) : 954-955.
  • 6Blackstock WP,Weir MP. Proteomics: Quantitative and physical mapping of Cellular proteins. Trends Biotechnol, 1999, 17 (3) : 121-127.
  • 7Patton WF. Detection technologies in proteome analysis. J Chrom- atogr B Analyt Technol Biomed Life Sei, 2002, 771 ( 1-2 ) : 3-31.
  • 8Hamdan M, Righetti PG. Modem strategies for protein quantifica- tion in proteome analysis:advan rages and limitations. Mass Spec- trom Rev,2002,21 (4) :287-302.
  • 9Wu WW, Wang G, Back S J, et al. Comparative study of three proteomie quantita- tire methods, DIGE, clCAT, and iTRAQ, u- sing 2D Gel-or LC-MALDI TOF/TOF. J Proteome Bes, 2006, 5 (3) : 651-658.
  • 10Anderson NL, Anderson NG, Haines LR, et al. Mass spectrome- tric quantitation of peptides and proteins using stable isotope standards and capture by anti-peptide antibmties ( SISCAPA ). J Proteome Res, 2004,3(2): 235-244.

同被引文献9

  • 1侯振江,张宗英.醛缩酶检测及其临床应用[J].世界今日医学杂志,2001,2(4):369-371. 被引量：6
  • 2AmitaI H, Govoni M, Maya R, et al. Role of infectious agents in systemic rheumatic diseases. Clin Exp Rheumatol, 2008, 26: 27- 32.
  • 3Weening JJ, D'Agati VD, Schwartz MM, et al. The classification of glomerulo nephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol,2004,15:241-250.
  • 4Bouchal P, Roumeliotis T, Hrstka R, et al. Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromato graphy-tandem mass spectrome- try(iTRAQ-2DLC-MS/MS) based quantitative pro teomic analy- sis. J Proteome Res,2009,8:362-373.
  • 5Glen A,Evans CA,GanCS, et al. Eight-plex iTRAQanalysis of variant metasta tic human prostate cancer cells identifies candi- date biomarkers of progressionAn exploratory study. Prostate, 2010,701313-1332.
  • 6Schett G, Dumortier H, Hoefler E, et al. B cell epitopes of the heterogeneous nuclear ribonucleoprotein A2: Identification of a new specific antibody marker for active lupus disease. Ann Rheum Dis, 2009,68 : 729-735.
  • 7Inokuchi J, Narula N, Yee DS, et al. Annexin A2 positively con- tributes to the maligant phenotype and secretion of IL-6 in DV145 prostate cancer cellsUJ3. Int J Cancer,2009,124 : 68-74.
  • 8Ao W,Zheng H,Chen XW, et al. Anti-annexin II antibody is as- sociated with thrombosis and/or pregnancy morbidity in an- tiphospholipid syndrome and systemic lupus erythematosus with thrombosis. Rheumatol Int, 20 l 0,13 : 865-869.
  • 9Perrot A, Hussein S, Ruppert V, et al. Identification of mutation al hot spots in LMNA encoding lamin A/C in patients with famil- ial dilated cardiomyopathy. Basic Res Cardiol,2009,10490-99.

引证文献1

国际免疫学杂志
2011年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部