摘要
目的比较益生菌联合三联疗法与传统三联疗法治疗幽门螺杆菌（Hp）的根治率、临床症状改善率、安全性、依从性及复发率。方法^14C呼气试验（UBT）、内镜下快速尿素酶（RUT）阳性的消化性溃疡、慢性浅表性胃炎患者178例，随机分A、B两组，A组用传统三联方案治疗14d，B组前1周用传统三联治疗，后2周益生菌12I服治疗。疗程结束停药2周后采用UBT试验检测Hp。结果疗程结束停药2周后，Hp根治率A组69．62％、B组83．72％，临床症状改善率A组62．29％、B组80．23％，两组差异均有统计学意义（P〈0．05）；药物依从性和不良反应发生率两组差异均无统计学意义（P〉0．05）。1年后复查UBT，复发率A组56．18％，B组22．47％，差异有统计学意义（P〈0．05）。结论益生菌联合三联疗法治疗Hp的根治率较传统的三联疗法高，且临床症状改善明显、复发率低。
Objective To compare eradication-, remission-, recurrence-and compliance rate between probiotics combined with triple therapy and traditional triple therapy in Helieobacter pylori infection. Methods 178 peptic ulcer and chronic shallow gastritis patients with Helicobaeter pylori infection （ by 14C urea breath test and rapid urease test） were divided into two groups randomly ： group A was assigned to receive traditional triple therapy for two weeks, while group B was treated with traditional triple therapy at the first week and probiotics in the following two weeks. Patients underwent a second ~4C urea breath test two weeks later. Results Both eradication rate and remission rate had a statistically significance in the present study. Helicobacter pylori eradication rates were 83.72% （ group B） and 69. 62% （ group A） （ P 〈 0. 05 ）, respectly. Remission rates of clinical symptoms were 80. 23% （ group B） and 62.29% （ group A） （ P 〈 0.05 ）. Incidences of compliance in group B were significantly lower than those of group A（P 〈0.05 ）. ~4C urea breath test were performed one year later, the comparison correlation between group A and group B also revealed a significant difference in recurrenee rates （56.18% versus 22.47% ; P 〈 0.05）. Conclusion Probiotics combined triple therapy had a higher eradication rate, higher clinical symptom remission rate and lower recurrence rate than traditional triple therapy for Helicobacter priori infection. It is a safe, well - tolerated,so it is worthy of clinic application widely.
出处
《浙江临床医学》
2011年第6期617-619,共3页
Zhejiang Clinical Medical Journal
关键词
益生菌
幽门螺杆菌
三联疗法
复方嗜酸乳杆菌
Probioties
Helieobaeter pylori
Triple therapy
Eosinophil - laetobacillus
Compound Tablets
