摘要
目的 观察造血干细胞移植（HSCT）患者出现真菌感染的临床特点,并探讨伊曲康唑抗真菌感染的疗效.方法 对该院2008年1月至2010年10月334例接受HSCT术治疗的病例真菌感染的临床治疗情况进行回顾性分析.90例HSCT患者术后被诊断为真菌感染,全部病例均予静脉注射伊曲康唑治疗,125～250毫克/次,第1、2天给予2次/天,第3天后给予1次/天,病情稳定后改为伊曲康唑口服液治疗.结果 HSCT患者术后真菌感染的发生率为27%,接受伊曲康唑治疗的患者有效率75.6%.确诊患者中10例（76.9%）有效,临床诊断病例58例（75.3%）有效.结论 HSCT患者术后真菌感染发病率高;伊曲康唑疗效明确,可用于HSCT患者术后患者抗真菌感染的治疗.
Objective To observe the clinical features of fungus infection in patients after hematopoietic stem cell transplantation （HSCT） and the curative effect of Itraconazole in the treatment of fungus infection. Methods 334 cases of patients, accepting HSCT during Jan. 2008 and Oct. 2010 in our hospital were retrospectively analyzed for the fungus infection and curative effect. Among all of the 334 cases, 90 cases were diagnosed as fungus infection, treated with intravenous injection of Itraconazole according to the manufacturer＇s manual. Results Fungus infection rate was 27% in all of the 334 cases. 68 cases of the 90 patients showed response to the therapy of Itraconazole,among which 10 were definite cases and 58 were probable cases. Conclusion There could be a relatively high incidence of fungus infection in patients after HSCT. hraconazole could have satisfactory clinical curative effect and could be a reliable choice for the treatment of fungus infection.
出处
《国际检验医学杂志》
CAS
2011年第11期1147-1148,共2页
International Journal of Laboratory Medicine
基金
国家自然科学基金资助项目(81070388)
重庆市自然科学基金重点项目(2009BA5056)
第三军医大学临床科研基金资助项目(2010D249)
关键词
伊曲康唑
造血干细胞移植
真菌
感染
治疗
Itraconazole
hematopoietie stem cell transplantation
fungi
infection
therapy
