期刊文献+

循环肿瘤细胞的研究进展 被引量:4

Advance on Clinical Impact of Circulating Tumor Cells
暂未订购
导出
摘要 循环肿瘤细胞(circulating tumor cells,CTCs)指自发或因诊疗操作由实体瘤或转移灶释放进入外周血循环的肿瘤细胞。CTCs能被看作液体活检,具有实时监测功能,是一种非侵入性的新型诊断工具,有助于早期发现肿瘤的微转移,可评估预后,在治疗的监测及个体化治疗上具有重要的临床意义。 Circulating tumor cells are(CTCs) are defined as cells that have detached, spontaneously or as a result of clinical operations, from a primary tumor or its metastatic lesions and circulate in the peripheral blood. CTCs can be regard as liq- uid biopsy, is a new noninvasive diagnostic tool with real--time monitoring function. Detection, monitoring, and molecular analysis of CTCs will provide a powerful approach for the detection of early disease, assessing prognosis , therapeutic response and individualized treatment in established cancers. Except that there must be some relationship between CTCs and tumor stages. The study of CTCs leads to significant improvement in clinical outcome of cancer patients.
出处 《医学与哲学(B)》 2011年第6期37-38,49,共3页 Medicine & Philosophy(B)
关键词 循环肿瘤细胞 诊断 预后 治疗 circulating tumor cells, diagnosis, prognosis, treatment
  • 相关文献

参考文献18

  • 1NtouroupiT G, Ashraf S Q, McGregor S B, el al. Dcteclion of circulaling tumour cells in peripheral blood wilh an aulomaled scan ning fluorescence microscope[J]. Br J Cancer, 2008,99(5) : 789-795.
  • 2Pachmann K, Clement J H, Schneider C E, et al. Standardized quantification of circulating peripheral tumor cells from lung and breast cancer[J].Clin Chem Eab Med, 2005,43(6):617-627.
  • 3Sastre J, Maestro M L, Puente J, et al. Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables [J]. Ann Oncol, 2008,19(5) :935-938.
  • 4Cristofanilli M, Budd G T, Ellis M .I, el al. Circulating lumor cells, disease progression, and survival in metastatic breast cancer [J]. N EnglJ Med,2004,351(8):781-791.
  • 5Maheswaran S, Sequist L V, Nagrath S, et al. Detection ofmuta tions in EGFR in circulating lungcancer cells[J].N Engl J Med, 2008,359(4) :366-377.
  • 6Meng S, TripathyD, SheteS, el al. uPARand HER 2 genesta tus in individual breast cancer ceils from blood and tissues[J]. Proe Natl Acad Sci U S A,2006,103(46) :17361-17365.
  • 7Kalluri R, Weinberg R A. The basics of epithelial mesenchymal transition[J].J Clin Invest, 2009,119((5):1420-1128.
  • 8Fidler I J. The pathogenesis nf cancer metastasis: the 'seed and soil' hypothesis revisited[J]. Nat Rev Cancer. 2003,3(6):,453-458.
  • 9Meng $, Tripathy D, Frenkel E P, et al. Circulating tumor cells m patients with breast cancer dormaney[J].Clin Canecer Res, 2004,10 (24) :8152--8162.
  • 10JordanCT, GuzmanMI., NobleM. Cancer stemcells[J]. N Engl J Med, 2006,355(12):1253-1261.

同被引文献59

  • 1周剑,王锡山.结直肠癌外周血循环肿瘤细胞的研究进展[J].中华结直肠疾病电子杂志,2013,2(1):25-28. 被引量:2
  • 2彭吉润,李澍.RT-PCR技术在肝癌患者循环肿瘤细胞检测中的应用[J].中国实验诊断学,2004,8(3):252-255. 被引量:1
  • 3黄同海,王正,李富荣.循环肿瘤细胞检测的研究新进展[J].中国肿瘤临床,2007,34(8):476-479. 被引量:15
  • 4黄同海,王正,李富荣,齐晖,周汉新,李青.纳米免疫磁珠富集和检测非小细胞肺癌患者循环肿瘤细胞的临床意义[J].中华肿瘤杂志,2007,29(9):676-680. 被引量:7
  • 5Ashworth TR. A case of cancer in which cells similar to those in the tumors were seen in the blood after death[J].Aust Med J,1869,(01):146-149.
  • 6Dittmar T,Heyder C,Gloria-Maercker E. Adhesion molecules and chemokines:the navigation system for circulating tumor(stem) cells to metastasize in an organ-specific manner[J].Clinical and Experimental Metastasis,2008,(01):11-32.
  • 7Langley RR,Fidler IJ. The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs[J].International Journal of Cancer,2011,(11):2527-2535.doi:10.1002/ijc.26031.
  • 8Wulfing P,Borchard J,Buerger H. HER-2 positive circulating tumor cells indicate poor clinical outcome in stage Ⅰto Ⅲ breast cancer patients[J].Clinical Cancer Research,2006,(06):1715-1720.doi:10.1158/1078-0432.CCR-05-2087.
  • 9Jiang W,Zhang H. Enrichment and detection of circulating tumor cells in peripheral blood[J].Chin Ger J Clin Oncol,2011,(04):240-244.doi:10.1021/tx200262d.
  • 10Cohen SJ,Punt CJ,Iannotti N. Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer[J].Annals of Oncology,2009,(07):1223-1229.doi:10.1093/annonc/mdn786.

引证文献4

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部