摘要
目的研究外周血循环肿瘤细胞(CTC)检测在小细胞肺癌(SCLC)转移早期诊断中的意义,为临床提供参考。方法选取茂名市人民医院2013-01—2014-12间收治的64例SCLC患者为观察组,选取同期60例非结核肺良性肿瘤患者为对照组,对比两组及观察组内不同分期患者的外周血CTC表达,探讨CTC与神经元特异性烯醇化酶(NSE)的相关性。结果观察组患者外周血CTC的阳性率均显著大于对照组;广泛期患者外周血CTC的阳性率均显著大于局限期患者,SCLC患者CTC表达水平与NSE呈明显正相关性。结论外周血CTC的表达与SCLC转移及恶化程度呈正相关,外周血CTC检测对SCLC转移的早期诊断具有重要意义,值得临床上推广应用。
Objective To analyze the significance of peripheral blood circulating tumor cells（ CTC） in early metastasis of small cell lung cancer（ SCLC）. Methods From January 2013 to December 2014,64 patients with small cell lung cancer treated in our hospital were selected as observation group,and 60 patients with non tuberculosis benign pulmonary disease were selected as control group. The expression of CTC in peripheral blood of two groups were detected and compared with the observation group,and the correlation between NSE and CTC was analyzed. Results The positive rate of CTC in the peripheral blood of the observation group was significantly higher than the control group. The positive rate of CTC in the peripheral blood of the patients was significantly higher than those in the limited period. The expression level of CTC in small cell lung cancer patients was significantly higher than the control group. Conclusion The expression of circulating tumor cells in peripheral blood was positively correlated with the metastasis and progression of small cell lung cancer. It was important for early diagnosis of small cell lung cancer patients. It was worthy of clinical application.
出处
《黑龙江医学》
2016年第2期151-153,共3页
Heilongjiang Medical Journal
关键词
小细胞肺癌
局限期
广泛期
外周血循环肿瘤细胞
Small cell lung cancer
Limitation
Extensive stage
Peripheral blood circulating tumor cells
