摘要
目的:探讨F asc in在胃癌及相应癌旁组织中的表达及其临床病理意义。方法:应用免疫组织化学SP法检测52例胃癌及相应癌旁组织中F asc in的表达。结果:胃癌组织中F asc in阳性表达率高于癌旁组织,分别为71%和9%(P<0.05),F asc in阳性表达与癌组织病理分级、外膜侵犯、淋巴结转移密切相关(P<0.05)。结论:胃癌组织中存在F asc in细胞,F asc in的表达与胃癌的分化程度、浸润深度及淋巴结转移有关,提示检测胃癌组织中F asc in的表达有助于评估肿瘤的恶性程度。
Objective：To study the expression and its clinical significance of Fascin in gastric carcinoma and adjacent mucosa.Methods：The expression of Fascin was detected by immunohistochemical SP methods in tissue samples from 52 cases of gastric carcinoma who received surgery operation only.Results：The quantity of expression of Fascin in adjacent mucosa（71%） was more than gastric carcinoma（9%）（P0.05）.The result showed that the Fascin expressions were related to primary tumor invasion,metastasis of lymphnodes,invasion depth（P0.05）.Conclusion：Fascin might be importion biological markers in Gastric carcinoma and they might be related to the biological behavior of Gastric carcinoma.Examination of Fascin may be helpful to judge biological behavior and prognosis of gastric carcinoma.
出处
《临床医药实践》
2011年第7期520-521,共2页
Proceeding of Clinical Medicine
