摘要
血管紧张素(angiotensin,Ang)-(1-7)是肾素-血管紧张素系统中除AngⅡ以外,另一种重要的调节肽,主要作用于Mas受体发挥作用。Ang-(1-7)通过与其Mas受体的结合,发挥血管扩张和抗细胞增殖等作用,抗衡AngⅡ与其AT1受体结合产生的血管收缩、血压升高、细胞增殖、尿钠潴留等作用。近年来研究发现,Ang-(1-7)及其Mas受体在局部组织生理功能中具有积极作用,在多种疾病病理过程中具有保护作用。
In addition to angiotensin Ⅱ , angiotensin-（1-7） is another important regulatory peptide of the renin-angiotensin system. It mainly binds with a specific receptor known as Mas, showing a vascular dilation and an anti-proliferation effect, which counterbalances the effects of angiotensin Ⅱ , including vasoconstriction, blood pressure increase, proliferation, urine retention, etc. Recent studies demonstrate that angiotensin-（1-7） and its Mas receptor play active roles in local physiological process and show an protective effect in many pathological conditions.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2011年第6期667-671,共5页
Academic Journal of Second Military Medical University
基金
国家"973"计划课题(2009CB521902)
上海市优秀学科带头人计划(10XD1405300)~~
