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哈萨克族食管癌中MMP-1、MMP-2、MMP-7、TIMP-1和MTA1的表达及其临床病理意义 被引量：6

The expression and significance of MMP-1,MMP-2,MMP-7,TIMP-1 and MTA1 in esophageal cancer of Kazaks
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摘要 目的:探讨在新疆哈萨克族食管癌组织中基质金属蛋白酶1、2、7(MMP-1、MMP-2、MMP-7)、基质金属蛋白酶抑制因子1(TIMP-1)和肿瘤转移相关基因1(MTA1)mRNA的表达及其临床意义。方法:采用RT-PCR方法检测75例哈萨克族食管癌标本中MMP-1、MMP-2、MMP-7、TIMP-1和MTA1 mRNA的表达水平,分析其表达与临床病理特征的关系。结果:MMP-1、MMP-2、MMP-7、TIMP-1和MTA1 mRNA在哈萨克族食管癌组织中的表达较正常组织增高,差异均具有统计学意义(P均<0.05);且MMP-2、MMP-7、MTA1 mRNA的表达与淋巴结转移有关(P<0.05),MMP-1、MMP-7 mRNA的表达与临床分期有关(P<0.05);TIMP-1与MMP-1、MMP-7、MTA1的表达呈正相关(r=0.446、0.458、0.333,P均<0.01)。结论:MMP-1、MMP-2、MMP-7、TIMP-1和MTA1 mRNA表达上调共同参与了哈萨克族食管癌的发生发展过程;MMP-2、MMP-7和MTA1可能是哈萨克族食管癌发生侵袭、转移的主导因素。 OBJECTIVE:To study expressions of matrix metalloproteinasel,2,7(MMP-1,MMP-2,MMP-7),tissue inhibitor of matrix metallo proteinase 1(TIMP-1)and metastasis associated gene 1(MTA1)in esophageal cancer tissue and normal tissue among Kazaks and to investigate the relationship between their expressions and clinical pathological features.METHODS:Using RT-PCR to detect the expressions of MMP-1,MMP-2,MMP-7,TIMP-1 and MTA1 in 75 esophageal cancer specimens.RESULTS:The mRNA expressions of MMP-1,MMP-2,MMP-7,TIMP-1 and MTA1 in cancer tissue were higher than those of normal tissues(P0.05).While the expression levels of MMP-2,MMP-7 and MTA1 mRNA were significantly related to the lymph node metastasis.The expression levels of MMP-1,MMP-7 mRNA were significantly related to the TNM stages(P0.05).The expression of TIMP-1 in the Kazak's esophageal cancer was positively related to the expressions of MMP-1,MMP-7,MTA1(r=0.446,0.458,0.333,respectively,P0.01).CONCLUSION:The overexpressions of MMP-1,MMP-2,MMP-7,TIMP-1 and MTA1 gene could have important roles in carcinogenesis of esophageal cancer in the Kazaks.Their synergistic effect could promote carcinogenesis and development of esophageal cancer.The MMP-2,MMP-7 and MTA1 genes may be the main players of progression and metastasis in esophageal cancer among Kazaks.
作者 李秀梅 陈艳 王洪江 庞作良 李卉 姜孝芳 古丽努尔.木哈依 谌宏鸣 李惠武 LI Xiu-mei;CHEN Yan;WANG Hong-jiang;PANG Zuo-liang;LI Hui;JIANG Xiao-fang;Gulinuer•Muhayi;CHEN Hong–ming;LI Hui–wu(School of Basic Medicine,Xinjiang Medical University,Urumgi 830011,Xinjiang,China;The Affiliated Tumour Hospital,Xinjiang Medical University,Urumgi 830011,Xinjiang,China)
机构地区 新疆医科大学基础医学院 新疆医科大学附属肿瘤医院
出处 《癌变·畸变·突变》 CAS CSCD 2011年第3期190-193,198,共5页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 国家自然科学基金项目(30950012)
关键词 食管癌 基质金属蛋白酶 基质金属蛋白酶抑制因子1 肿瘤转移相关基因1 esophageal cancer matrix metalloproteinase tissue inhibitor of matrix metalloproteinase 1 metastasis associated gene 1
分类号 R734.2 [医药卫生—肿瘤]
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参考文献13

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共引文献7

同被引文献67

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癌变·畸变·突变
2011年 第3期

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