摘要
目的：探讨格林巴利综合征（ＧＢＳ）腓神经活检的光、电镜表现与临床诊断及预后的关系。方法：对２６例ＧＢＳ患者腓神经活检进行了光镜及电镜观察。结果：有髓神经纤维均呈不同程度的减少、退行性变及脱髓鞘。在病变早期髓鞘改变呈松解、变形、断裂及多层状，部分增厚突向轴浆内。严重者则髓鞘呈空泡化、空网状及形成髓球状，并挤压及占据整个轴浆，部分轴索变性坏死及葱头样肥大神经改变。雪旺细胞增生及无髓神经纤维减少及萎缩。毛细血管内皮细胞增生及细胞连接增宽等。间质内可见吞噬细胞、淋巴细胞浸润。病理形态改变与临床病程长短及患者感觉障碍均有相关性。结论：对ＧＢＳ患者腓神经活检的光镜及电镜观察可以作为临床诊断ＧＢＳ及判断预后的指标之一。
Purpose To study relationship between the changes of light and electron microscope in sural nerves and clinical diagnosis and the prognosis of GuillainBarre syndrome(GBS). Methods Biopsy of sural nerves in 26 cases of GBS were studied by using light and electron microscope. Results Myelinated nerve fiber was decrease, retrogression and demyelination. Early pathologic morphology showed that myelin sheath was loosed, distorted and interrupted. Some spherical hyperplasia of myelin were toward neuron. Demyelination and vaculization of myelin sheath were observed in serious cases. Some myelinated nerve fiber was degenerated. Schwanns cells proliferated and unmyelinated nerve fiber decreased. The hyperplasia of endothelial cells of vascular capillary was found. The severe degree of the pathologic morphology had correspondence with the clinical symptoms. Conclusion There are significant changes which indicates in the clinical diagnosis and prognosis of patients.
出处
《临床与实验病理学杂志》
CAS
CSCD
1999年第3期202-204,I031,共4页
Chinese Journal of Clinical and Experimental Pathology
