摘要
缺血性脑卒中已成为世界上导致人类死亡的第二大疾病,大量研究证明,缺血及再灌注过程中产生的自由基在脑损伤中起关键作用,使得自由基清除剂成为治疗缺血性脑血管病的研究热点,很多自由基清除剂类药物被合成并先后进入临床试验,包括代表药物依达拉奉成功在日本上市。本文将综述有关治疗缺血性脑卒中的自由基清除剂的最新研究进展,探讨此类药物在研究过程中所遇到的问题并展望此类药物在治疗缺血性脑卒中疾病中的治疗前景。
Ischemic stroke is the second leading cause of death worldwide.Plenty of studies supported that free radicals are generated in the brain during ischemic-reperfusion injury and these radicals play important roles in the injury processes.Several free radical scavengers have been developed and some of them have progressed into clinical trials.One of them,edaravone,has been approved by the regulatory authority in Japan for the treatment of stroke patients.The purpose of this article is to review the current development of the radical scavengers treating with cerebral ischemic,and discuss the problems encountered and look into the future development of the free radical scavengers in the treatment of ischemic stroke.
作者
王晓金
孙建国
彭英
王广基
WANG Xiao-jin;SUN Jian-guo;PENG Ying;WANG Guang-ji(Key Lab of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,Jiangsu,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2011年第4期461-467,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
中央高校基本科研业务费专项资助(JKP2009007)
"十一五"重大新药创制项目资助(2009ZX09304-001)
"十二五"重大新药创制项目资助(2011ZX09102-003-02)
