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七氟醚麻醉对体外循环心脏手术患者围术期血清HO-1水平的影响 被引量：7

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摘要 目的观察七氟醚麻醉对体外循环心脏手术患者围术期血清脑血红素氧合酶-1(HO-1)水平的影响。方法体外循环心脏手术患者40例,随机分为观察组和对照组,各20例。观察组采用七氟醚复合异丙酚、芬太尼麻醉,对照组用异丙酚、芬太尼麻醉。分别于麻醉前(T0)、体外循环前(T1)、体外循环停止时(T2)、关胸时(T3)取两组患者颈内静脉血,分离血清,采用Western blot法检测其中的HO-1。结果观察组T2、T3血清HO-1水平较对照组明显升高(P均<0.05)。结论体外循环心脏手术患者麻醉用药中加用七氟醚可提高患者体外循环停止时和管胸前血清HO-1水平。
作者 陈燕 陈文栋 刘曼
机构地区 昆明医学院第一附属医院
出处 《山东医药》 CAS 北大核心 2011年第22期101-102,共2页 Shandong Medical Journal
关键词 七氟醚 体外循环 心脏外科手术 脑血红素氧合酶-1
分类号 R614 [医药卫生—麻醉学]
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参考文献11

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山东医药
2011年 第22期

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