摘要
目的:探讨阿立哌唑对患者心电图的影响。方法:85例精神分裂症患者随机分成研究组(43例)及对照组(42例),分别使用阿立哌唑与氯氮平治疗;于治疗前与治疗后4周、8周检查心电图。结果:阿立哌唑与氯氮平对精神分裂症患者的心电图均有影响,但阿立哌唑组所致心电图改变发生率明显低于氯氮平组(P<0.01),心电图异常程度轻,以窦性心动过速为主。结论:阿立哌唑可引起心电图发生改变,但其发生率低,心电图改变程度轻,安全性较大。
Objective：To explore the change of EKG caused by Aripiprazole. Methods：85 inpatients with schizophrenia were randomly assigned to two groups; the experimental group （43cases）and the control group （42cases）. The patient in the two groups were treated by Aripiprazole or Clozapine respectively,and were checked to EKG before and after the treatment 4th and 8th week. Results：Both of Aripiprazole and Clozapine had effected to EKG of patients. In the experimental group the abnormal rate of EKG was lower than that in the control group （P 〈0.01 ）, and the Severity of electrocardiography abnormality was slight. The most of them was sinus tachycardia. Conclusion： Aripiprazole can cause electrocardiography abnormality,but the abnormal rate is lower and the Severity is slight. It has a favorable safety.
关键词
阿立哌唑
氯氮平
精神分裂症
心电图
Aripiprazole
Clozapine
Schizophrenia
Electrocardiogram （EKG）
