摘要
对氯氮平治疗的１３２例病人进行调查，并就有粒细胞改变的８５例加以分析。结果提示：氯氮平治疗所致粒细胞改变与服药剂量、单一或合并用药无关，性别差异显著，随着用药时间增长，粒细胞改变发生率有减少趋势。氯氮平疗效肯定，副反应并无国外报道的那么严重。
Abstract Objective:To study the effect of clozapine on granulocyte count.Method:The granulocyte count of 132 psychiatric patients on clozapine treatment was investigated.Results:Granulocyte counts were not related to clozapine dosage,the use of combination drug therapy,or patients sex.Granulocyte count was less likely to occur as treatment was prolonged.Discussion:Clozapine showed a reliable therapeutic effect according to our clinical experience.The feared side-effect of agranulocytosis was not as common as it is reported in the Western literature.In our experience,it occurred during the first 2-4 weeks of treatment and was reversible.Hereditary,allergic and immunological factors could be involved.
出处
《临床精神医学杂志》
1996年第3期148-149,共2页
Journal of Clinical Psychiatry
