摘要
目的：研究丹皮酚对鹌鹑实验性动脉粥样硬化的抑制作用。方法：观察丹皮酚灌胃给药（６００，３００ｍｇ·ｋｇ－１）后在鹌鹑实验性动脉粥样硬化形成中调节血脂、改善血液流变学、减轻主动脉脂质斑块形成的作用。结果：口饲丹皮酚可明显降低实验动物血清ＴＣ，ＴＧ，ＬＤＬ，ｖＬＤＬ，ａｐｏＢ１００含量，提高ＨＤＬ含量及ＨＤＬ／ＴＣ，ＨＤＬ２／ＨＤＬ３，ａｐｏＡ１／ａｐｏＢ１００比值；不同程度地降低低切变率下全血比粘度、血浆比粘度、纤维蛋白原比粘度、红细胞聚集性。显著减少主动脉壁及肝脏ＴＣ含量，缩小斑块面积，抑制主动脉脂质斑块形成。
Objective:To study the effect of paeonol on experimental atherosclerosis in quails caused by high lipid feeding.Method:The effects of oral administration of 300 and 600mg/kg of paeonol on lipid levels in serum,hemorrheology and aortic intimal abnormalities were investigated.Result:Paeonol decreased TC,TG,LDL,vLDL,APOB 100 levels in serum and TC levels in aorta and liver.The ratios of HDL/TC,HDL 2/HDL 3, apoA 1/apoB 100 were elevated.In addition,the drug reduced the whole blood viscosity,Plasma viscosity and plasma fibrinogen,and inhibited erythrocyte aggregation.Conclusion:Oral administration of paeonol can reduce the development of atherosclerosis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1999年第8期488-490,共3页
China Journal of Chinese Materia Medica
关键词
丹皮酚
动脉粥样硬化
脂质
血液流变学
中药
paeonol
atherosclerosis
lipid
hemorrheology (original article on page 488)
