摘要
目的:探讨淋巴管生成因子LYVE-1及Prox-1的定量表达与宫颈癌淋巴结转移的相关性。方法:收集宫颈鳞癌手术标本24例,运用半定量RT-PCR技术对淋巴管生成因子LYVE-1和Prox-1进行分析,分别比较这两种因子在切除标本的肿瘤组织、癌旁组织中表达的差异。结果:Prox-1在肿瘤及癌旁组织表达分别为1.52±0.26和0.46±0.19,LYVE-1在肿瘤及癌旁正常组织的表达分别为1.37±0.21和0.56±0.12。Prox-1及LYVE-1在肿瘤组织的表达均高于癌旁组织(P均<0.01),与肿瘤的发生有关。并且它们的表达与淋巴结转移有相关性(P<0.01)。结论:Prox-1及LYVE-1表达升高与宫颈癌发生及淋巴结转移有一定关系,检测该指标对了解宫颈癌的侵袭和转移具有一定价值。
Objective： To investigate the relevance between the expression of lymphangiogenesis factor and cervical lymph node metastasis. Method：This study has collected 24 cases of surgical specimens of cervical squamous cell carcinoma＇with lymph node metastasis,using semi-quantitatie reverse transcription PCR technique to analyse the expression of lymphangiogenic factor LYVE-l and Prox-J, and compared the differential expression of these two factors in tumor and adjacent tissue respectively. Results：The relative expression of Prox-1 in tumor and tissue adjacent to the tumor were 1.52±0.26 and 0.46±0.19（P〈0.01 ） ,of LYVE-1 were 1.37±0.21 and 0.56±0.12 （P〈0.01）. They had higher expression in cervical tissues than adjacent tissues, related with the development of cervical cancer and lymph node metastasis. Conclusion：Prox-1 and LYVE-l were correlated with cervical cancer and lymph node metastasis,suggesting that detection of LYVE-1 and Prox-1 may be valuable in the evaluation of invasiveness and metastasis of cervical cancer.
出处
《现代妇产科进展》
CSCD
北大核心
2011年第5期365-368,共4页
Progress in Obstetrics and Gynecology
