摘要
目的 探讨神经肽 Y( N P Y) 与神经降压素( N T) 在银屑病发病中的作用。方法 采用放射免疫分析法对32 例银屑病患者进行血浆 N P Y 与 N T 的含量检测。结果 与25 例正常人比较,银屑病患者血浆中 N P Y 水平显著增高,差异具有显著性意义( P< 0 .05) 。 N T 水平较正常人明显降低( P<0 .05) 。相关分析显示患者 N P Y 含量增高与 N T 含量下降呈明显负相关( r = - 0 .76 , P< 0 .01) 。结论 具有强烈缩血管作用的 N P Y 作为一种致血管形成因子和 N T 共同参与了银屑病发病的病理过程。研究其变化规律对判断病情、指导治疗具有重要的临床意义。
Objective To explore the role of NPY and NT in the pathogenesis of psoriasis.Method We detected the content of NPY and NT in 32 psoriasis patients by radioimmunology method.Reslts Compared with 25 normal subjects,level of NPY in psoriasis patients significantly increased(P<0.05),level of NT in psoriasis patients significantly decreased(P<0.05),Correlative analysis indicated that content of NPY in patients correlated negatively with NT significantly(r=-0.76).Conclusion NPY,which has strong effect of straitening blood vessal,reacted on pathological course as factor of blood vessel tating shape togather with NT.Study of it's regulation of change has important clinical significance for judgement of patient's condition and direction of therapy.
出处
《中国皮肤性病学杂志》
CAS
北大核心
1999年第5期267-268,共2页
The Chinese Journal of Dermatovenereology