摘要
目的： 观察 Ｎｏｒｐｌａｎｔ 致子宫不规则出血时内膜血管的变化， 探讨二者的关系。方法：用组织学和免疫组织化学方法对使用 Ｎｏｒｐｌａｎｔ 后 （０５ 、１ ａ 及＞ ２ ａ） 月经规律及有子宫不规则出血者的子宫内膜进行形态学、内膜血管内皮细胞 Ｃ Ｄ３４ 和基膜层粘连蛋白 （ Ｌ Ｎ） 观察。结果： Ｎｏｒｐｌａｎｔ 使用者子宫内膜均无典型的周期特点， 血管内皮变薄； 出血不规则的内膜血管基膜 Ｌ Ｎ 明显减少。结论： Ｎｏｒｐｌａｎｔ 使用者子宫出血不规则与内膜血管内皮变薄和基膜 Ｌ Ｎ减少有密切关系。
Objective:To investigate changes of endometrial vessels of irregular bleeding after using Norplant.Methods:Endometrium with regular or irregular bleeding after Norplant implantation for half a year,one year or more than two years were studied morphologically,and were showed CD 34 and laminin(LN) by immunohistochemistry.The normal cyclical endometrium were used as control.Results:Normal cyclical changes disappeared in endometrium and the endothelium of vessels got thinner in the Norplant users.LN in the vascular basement membrane of endometrium of irregular bleeding decreased obviously.Conclusion:The thinner endothelium of vessels and decreasing LN of the vascular basement membrane of endometrium were closely related with the abnormal uterine bleeding of Norplant users.
出处
《中日友好医院学报》
1999年第4期207-209,共3页
Journal of China-Japan Friendship Hospital
基金
北京市自然基金
关键词
子宫规则出血
避孕药
层粘连蛋白
抗原
metrorrhagia
contraceptive agents
laminin
antigens,CD 34
