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肥大细胞在类风湿关节炎中的致病机制及研究新进展 被引量：4

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摘要 早在20多年前，Bromley等就发现类风湿关节炎（theumatoid arthritis，RA）骨破坏的区域分布着肥大细胞，但其作用一直不详。直到2002年，通过动物研究发现关节炎的发生依赖于肥大细胞的存在，人们才逐渐认识到肥大细胞除参与急性过敏反应外，在慢性炎症中也发挥了重要作用，
作者 李春 穆荣
机构地区 北京大学人民医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2011年第5期351-353,共3页 Chinese Journal of Rheumatology
基金 国家重点基础研究发展计划项目（973计划）
关键词 类风湿关节炎 肥大细胞 致病机制 急性过敏反应 区域分布 慢性炎症 骨破坏
分类号 R593.22 [医药卫生—内科学]
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参考文献26

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二级参考文献13

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共引文献2

同被引文献77

  • 1Kolly L,Busso N,Palmer G. Expression and function of the NALP3 inflammasome in rheumatoid synovium[J].Immunology,2010,(2):178-185.doi:10.1111/j.1365-2567.2009.03174.x.
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  • 3Shao XT,Feng L,Gu LJ. Expression of interleukin-18,IL-18BP,and IL-18R in serum,synovial fluid and synovial tissue in patients with rheumatoid arthritis[J].Clinical and Experimental Medicine,2009.215-221.
  • 4Gaujoux-Viala C,Mouterde G,Baillet A. Evaluating disease activity in rheumatoid arthritis:which composite index is best?. A systematic literature analysis of studies comparing the psychometric properties of the DAS,DAS28,SDAI and CDAI[J].Joint Bone Spine:Revue du Rhumatisme,2012.149-155.
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中华风湿病学杂志
2011年 第5期

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