摘要
目的近年来,国外大量研究发现,慢性阻塞性肺疾病（COPD）常合并其他系统性疾病,如冠心病、高血压病和糖尿病。国内尚缺乏这方面的资料分析。本研究目的是调查北京2所医院的COPD患者合并冠心病、高血压病或糖尿病的患病率。方法分析了2007年1月-2009年5月间因慢性阻塞性肺疾病（COPD）急性发作住院的患者468例。冠心病诊断条件是根据既往有心肌梗死病史或冠状动脉造影提示冠状动脉狭窄。结果全部468例COPD患者,男性319例,女性149例,年龄70.6±9.2岁,FEV147.7%±18.9%预计值。单纯COPD有214例（45.7%）,COPD合并肺外疾病有254例（54.3%）,其中冠心病73例（15.6%）,高血压病200例（42.7%）,糖尿病80例（17.1%）。高血压是COPD并发冠心病的危险因素[odds ratio（OR）：3.163,95%可信区间（95%CI）：1.431-6.991];年龄（OR：1.042,95%CI：1.012-1.073）和体质指数（OR：1.122,95%CI：1.049-1.200）是COPD并发高血压的危险因素;C反应蛋白（OR：1.020,95%CI：1.005-1.034）和体质指数（OR：1.163,95%CI：1.062-1.274）是COPD并发糖尿病的危险因素。结论 COPD并发其他疾病在国内也很常见,年龄、体质指数和CRP是其高危因素。
Objective A lot of studies showed chronic obstructive pulmonary disease（COPD） was associated with some comorbid diseases,including ischaemic heart disease,hypertention and diabetes mellitus.Few data were obtained about comorbid condition in COPD in China.The study was to investigate these comorbid diseases in patients with COPD in two hospitals in Beijing.Methods We analyzed the data from 468 patients hospitalized with exacerbation of COPD from January 2007 to May 2009.The diagnosis of ischaemic heart disease was based on previous history of myocardial infarction or evidence of coronary stenosis from coronary angiography.Results A total of 468 COPD patients（319 men and 149 women;mean age 70.6±9.2 years;and predicted mean FEV1,47.7%±18.9%） were included.Two hundred and fourteen COPD patients had no comorbid disease.Two hundred and eighteen COPD patients had comorbid diseases,in which 42.7% had hypertention,15.6% had ischaemic heart disease（CHD） and 17.1% had diabetes mellitus.Hypertention was associated with a higher risk of comordid CHD in COPD[odds ratio（OR）：3.163,95% confidence interval（95%CI）：1.431-6.991].Age（OR：1.042,95%CI：1.012-1.073）and BMI（OR：1.122,95%CI：1.049-1.200） were associated with comordid hypertention in COPD.C-reactive protein（CRP）（OR：1.020,95%CI：1.005-1.034） and BMI（OR：1.163,95%CI：1.062-1.274） were associated with comorbid diabetes mellitus in COPD.Conclusion Comorbid diseases in COPD are also common in China.Older age,higher BMI and CRP are associated with a higher risk of comorbid disease in COPD.
出处
《医学研究杂志》
2011年第4期47-49,共3页
Journal of Medical Research
基金
北京市科委基金资助项目(z080507030808025)
关键词
慢性阻塞性肺疾病
缺血性心脏病
高血压
糖尿病
Chronic obstructive pulmonary disease
Ischaemic heart disease
Hypertention
Diabetes
