摘要
目的研究不同性别对寒冷的耐受力的差异。方法对寒冷环境下小鼠的行为及死亡率进行观察,比较不同性别的耐寒性差异。结果在寒冷环境下,小鼠除了行为发生改变外,其雄鼠的死亡率高于雌鼠。寒冷组小鼠的死亡率高于对照组(P<0.05),其中寒冷组雄鼠的死亡率明显高于雌鼠(P<0.05)。结论雄性小鼠的耐寒性相对较低,尤其以老龄鼠为甚。这种现象可能是由于棕色脂肪组织活性、性激素、耐寒基因表达等的差异造成的。
Objective To investigate the discrepancy of cold resistance in different gender.Methods The behavior and mortality of mice were observed in the cold environment,and the cold resistance between male and female was studied as well.Results Except serial behavioral difference,the male mortality under coldness was higher than females.The mouse mortality in cold group was higher than the control group（P〈0.05）.Moreover,the male′s mortality in cold group was significantly higher than the mortality of females（P〈0.05）.Conclusion The male mice were relatively low tolerant to coldness,particularly for the aging mice.The phenomenon probably is caused by some differences between male and female,such as brown adipose,sexual hormones,and the cold resistance genes expression.
出处
《医学研究杂志》
2011年第4期44-46,共3页
Journal of Medical Research
基金
国家自然科学基金面上项目(30771140
30670688)
河南省教育厅自然科学研究项目(2007180008)
河南大学自然科学基金资助项目(05YBZR031)
关键词
耐寒性
性别差异
寒冷应激
棕色脂肪
Cold resistance
Sexual difference
Cold stress
Brown adipose
