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肺癌中HIF-1α、VEGF表达及其与放射治疗关系的研究进展 被引量：6

Progress in HIF-1α and VEGF Expressions in Lung Cancer and Their Relationship with Radiotherapy
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摘要 为解决非小细胞肺癌放射治疗后期肿瘤乏氧而产生放射耐受,各国学者尝试使用乏氧细胞放疗增敏剂、高压氧疗、中子疗法以及放疗前辅助化疗等方法,但疗效无明显提高。靶向药物的出现看似能解决一定的问题,但往往对自身机体有一定的损伤,并且有同时耐受的现象发生,如何解决这些问题,是肿瘤放化疗研究热点。研究发现,肺癌患者HIF-1α及VEGF蛋白表达情况对于放射治疗中应用增敏剂及治疗方案的制定有一定的意义。文章主要对此综述。
作者 汤忠祝 沈朋
机构地区 浙江大学医学院 浙江省肿瘤医院 浙江大学医学院附属第一医院
出处 《中国肿瘤》 CAS 2011年第5期367-371,共5页 China Cancer
基金 浙江省医药卫生科学研究基金(2008B026)
关键词 肺癌 放射疗法 低氧诱导因子-1α(HIF-1α) 血管内皮生长因子(VGEF)
分类号 R734.2 [医药卫生—肿瘤]
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参考文献39

  • 1Gassmann M, Chilov D, Wenger RH. Regulation of the hypoxia-inducible factor-1 alpha. ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus [J]. Adv Exp Med Biol, 2000, 475: 87-99.
  • 2Jiang BH, Zheng JZ, LeungSW, et al. Transactivation and inhibitory domains of hypoxia-inducible factor 1 alpha. Modulation of transcriptional activity by oxygen tension [J]. J Biol Chem, 1997, 272(31): 19253-19260.
  • 3Hyder S, Murthy L, Stancel G. Progestin regulation of vascular endothelial growth factor in human breast cancer cells[J]. Cancer Res, 1998, 58(2): 392- 395.
  • 4Leung DW, Cachianes G, Sanzo WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen [J]. Science, 1989, 246 (4935): 1306- 1309.
  • 5Senger DR, Ledbetter SR, Claffey KP, et al. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3integrin, osteopontin, and thrombin[J]. Am J Pathol, 1996, 149 (1): 293-305.
  • 6Oku T, Tjuvajev J, Miyagawa T, et al.Tumor growth modulation by sense andantisense vascular endothelial growth factor gene expression:effects on angiogenesis, vascular permeability, blood volume, blood flow, flurodeoxyglucose uptake, and proliferation, blood human melanoma intracerbral xenografts [J]. Cancer Res, 1998, 58(18): 4185-4192.
  • 7糜军,王建华,陈诗书.可溶性VEGF受体基因sflt-1与反义VEGF核苷酸对新生血管形成的影响[J].癌症,2002,21(5):464-468. 被引量：10
  • 8van Baardwijk A, Dooms C, van Suylen R J, et al. The maximum uptake of 18F-cleoxyglueose on positron emission tomography scan correlates with survival, hypoxia inducible factor-lalpha and GLUT-1 in non-small cell lung cancer[J]. Eur J Cancer, 2007, 43(9): 1392- 1398.
  • 9Shyu KG, Hsu FL, Wang M J, et al. Hypoxia-inducible factor 1 alpha regulates lung adenocarcinoma cell invasion [J].Exp Cell Res,2007,313(6): 1181-1191.
  • 10Zuo S, Ji Y, Wang J, et al. Expression and clinical implication of HIF- 1 alpha and VEGF-C in non-small cell lung cancer [J]. J Huazhong Univ Sei Technolog Med Sci, 2008, 28 (6):674- 676.

二级参考文献17

  • 1孙宝华.凋亡抑制蛋白与肿瘤[J].国外医学：肿瘤学分册,2000,27:3-6.
  • 2Kuwai T, Kitadai Y,Tanaka S, et al. Expression of hypoxia - inducible factor - 1 alpha is associated with tumor vascularization in human colorectal carcinoma[J]. Int J Cancer,2003,105 (2):176 - 181.
  • 3Lee CH,Lee MK,Kang CD,et al. Differential expression of hypoxia inducible factor - 1 alpha and tumor cell proliferation between squamous cell carcinomas and adenocarcinomas among operable non- small cell lung carcinomas[ J]. J Korean Med Sci, 2003,18 (2) :196 -203.
  • 4Goodman RH, Smolik S. CBP/p300 in cell growth, transformation, and development[ J]. Genes Dev,2000,14 ( 13 ) :1553 - 1577.
  • 5Dames SA, Martinez - Yamout M, De Guzman RN, et al. Structural basis for Hif - 1 alpha/CBP recognition in the cellular hypoxic response[J].Proc Natl Acad Sci U S A,2002,99(8) :5271 -5276.
  • 6Gu YZ, Moran SM, Hogenesch JB, et al. Molecular characterization and chromosomal localization of a third alpha - class hypoxia inducible factor subunit, HIF3 alpha [J].Gene Expr, 1998,7 ( 3 ) : 205 - 213.
  • 7Birner P, Schindl M, Obermair A, et al. Overexpression of hypoxia - inducible factor 1 alpha is a marker for an unfavorable prognosis in early- stage invasive cervical cancer[ J ]. Cancer Res,2000,60 ( 17 ) :4693 - 4696.
  • 8Marxsen JH, Schmitt O, Metzen E, et al. Vascular endothelial growth factor gene expression in the human breast cancer cell line MX - 1 is controlled by O2 availability in vitro and in vivo[ J]. Ann Anat ,2001,183 ( 3 ) :243 - 249.
  • 9Konno R,Yamakawa H,Utsunomiya H,et al.Expression of survivin and Bcl-2 in the normal human endometrium[J].Mo1 Hom Reprod,2000,6(6):529-534.
  • 10Brekken RA,Thorpe PE.Vascula endot helial growt h factor and vascular targetin of solid tumors[J].Anticancer Res,2001,21(6B):4221-4229.

共引文献19

同被引文献57

  • 1贾英杰,张莹,孙一予,陈军.消岩汤不同时段参与化疗治疗非小细胞肺癌临床疗效观察[J].天津中医药大学学报,2006,25(3):164-165. 被引量：14
  • 2Ahmad N,Feyes DK,Nieminen AL,et al. Green tea constituent epigallocatechin-3-gallate and induction of apop- tosis and cell cycle arrest in human carcinoma cells [J]. J Nail Cancer Inst, 1997,89(24):1881-1886.
  • 3Wang H,Bian S,Yang CS. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1a[J]. Carcinogenesis, 2011,32(12): 1881-1889.
  • 4Zhang Q, Fu H, Pan J,et al. Effect of dietary polyphenon E and EGCG on lung tumorigenesis in A/J mice[J]. Pharm Res,2010,10(6):1066-1071.
  • 5Shankar S,Suthakar G,Srivastava RK.Epigalloeatechin-3- gallate inhibits cell cycle and induces apoptosis in pancrea-tie cancer[J]. Front Biosci ,2007,10(12): 5039-5051.
  • 6Lu X,Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis [J]. Clin Cancer Res, 2010,16(24):5928-5935.
  • 7Hung JJ, Yang MH, Hsu HS, et al. Prognostic significance of hypoxia-inducible factor-lalpha,TWIST1 and Snail expression in resectable non-small cell lung cancer[J]. Thorax, 2009,64(12): 1082-1089.
  • 8Dai CX,Gao Q,Qiu SJ,et al. Hypoxia-inducible factor-1 alpha,in association with inflammation,angiogenesis and MYC,is a critical prognostic factor in patients with HCC after surgery[J]. BMC Cancer,2009,9:418-925.
  • 9Ellis L,Hammers H,Pih R. Targeting tumor angiogenesis with histone deacetylase inhibitors [J]. Cancer Lett, 2009,280 (2) : 145-153.
  • 10Semenza GL. Expression of hypoxia - inducible factor 1: mechanisms and consequences[J]. Biochem Pharmacol, 2000,59 (1) : 47-53.

引证文献6

二级引证文献21

中国肿瘤
2011年 第5期

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