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巨细胞病毒感染致婴儿听力受损的早期干预及随访 被引量:10

Follow up of infant with early intervention of cytomegalovirus infection hearing impairment
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摘要 目的观察婴儿期巨细胞病毒(CMV)感染后脑干听觉诱发电位(BAEP)的变化及对于早期以更昔洛韦为主综合治疗的患儿听力恢复情况。方法选取45例听力异常的CMV感染婴儿,分析其脑干听觉诱发电位的特点,给予更昔洛韦抗病毒、营养脑细胞及听觉刺激法等早期综合干预方案,随访4~6个月,以观察治疗后听力恢复情况。结果双耳出现异常35例(77.8%),单耳出现异常10例(22.2%);仅客观听阈轻度增高28例(62.2%),客观听阈轻度增高伴有波的异常改变5例(11.1%),仅客观听阈中重度增高1例(2.2%),客观听阈中重度增高伴有波的异常改变11例(24.5%),未发现有客观听阈正常而波有异常改变的病例。更昔洛韦等早期干预治疗后,在4~6个月随访时,除4例失访外,治愈(BAEP恢复正常)36例(87.8%),有效4例(9.8%),无效1例(2.4%),总有效率97.6%。结论 CMV感染可引起婴儿不同程度的听力受损,最常表现为客观听阈轻度增高,其次为客观听阈中重度增高伴有波的改变。更昔洛韦为主的早期综合干预,对CMV感染引起的婴儿听力损害的疗效满意、安全,值得临床推广。
出处 《临床儿科杂志》 CAS CSCD 北大核心 2011年第4期351-354,共4页 Journal of Clinical Pediatrics
关键词 巨细胞病毒 听力受损 脑干听觉诱发电位 更昔洛韦 cytomegalovirus hearing impairment brainstem auditory evoked potential ganciclove
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参考文献18

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二级参考文献26

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