Yohimbine protects against endotoxin-induced acute lung injury by blockade of alpha 2A adrenergic receptor in rats 被引量：3

Yohimbine protects against endotoxin-induced acute lung injury by blockade of alpha 2A adrenergic receptor in rats

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摘要 Background Alpha 2A adrenergic receptor （AR） is a subtype of （]2 AR belonging to G protein-coupled receptors, and exerts a variety of biological effects. Recent studies have demonstrated that the a2A AR activation was closely related with inflammatory reaction. The present study aimed to investigate the influence of a2A AR antagonist, yohimbine, on the severity of endotoxin-induced acute lung injury in rats. Background Alpha 2A adrenergic receptor （AR） is a subtype of （]2 AR belonging to G protein-coupled receptors, and exerts a variety of biological effects. Recent studies have demonstrated that the a2A AR activation was closely related with inflammatory reaction. The present study aimed to investigate the influence of a2A AR antagonist, yohimbine, on the severity of endotoxin-induced acute lung injury in rats.

作者 LIN Ying ZHU Xi YAO Wan-zhen YANG Yan-lin A La-ta CHEN Li

机构地区 Department of Surgical Intensive Care Unit Department of Respiratory Medicine Central Laboratory

出处《Chinese Medical Journal》 SCIE CAS CSCD 2011年第7期1069-1074,共6页 中华医学杂志（英文版）

关键词 acute lung injury a2A adrenergic receptor inflammatory response acute lung injury a2A adrenergic receptor inflammatory response

分类号 O [理学]

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Chinese Medical Journal

2011年第7期

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