摘要
目的 观察含呋哺唑酮的四联疗法联合口腔洁治进行补救治疗对幽门螺杆菌根除多次失败患者的治疗效果及根除率.方法 入选者为幽门螺杆菌根除治疗失败至少2次或以上,经13C-UBT或RUT检测确诊幽门螺杆菌感染的患者104例,随机分为2组,一组64例给予四联方案（雷贝拉唑＋铋剂＋阿莫西林＋呋喃唑酮）10 d,同时进行口腔洁治;另一组40例仅给予四联方案（雷贝拉唑＋铋剂＋阿莫四林＋呋喃唑酮）10 d,不进行口腔洁治.两组治疗结束后,停药1个月后复查13C-UBT.比较两组患者的幽门螺杆菌根除率.结果 口腔洁治组64例,成功根除55例,根除率85.9%（55/64）.未进行口腔洁治组40例,成功根除29例,根除率72.5%（29/40）.两组根除率无明显统计学差异（P=0.091）.结论 针对幽门螺杆菌根除多次失败者,联合口腔洁治的四联疗法与不行口腔洁治组相比,可以提高根除率,两组比较虽然没有统计学差异,但其研究结果表明了口腔作为幽门螺杆菌的定植地可能是导致部分患者多次根除失败的重要原因之一.
Objective To observe the effect of furazolidone quadruple regimen plus dental plaque removal procedures as rescue treatment of refractory H.pylori infection.Methods A total of 104 patients with H.pylori positive [13 C-urea breath test （UBT） or rapid urease test positive] failing in previous treatment two or more were enrolled and divided into 2 groups.One group （n = 64） were given quadruple regimen [proton pump inhibitor （PPI） ＋ bismuth ＋ amoxicillin ＋ furazolidone,10 days] treatment and dental plaque removal treatment.And the others （n =40） received only quadruple regimen treatment.The status of H.pylori was detected by 13 C-UBT at 4 weeks post-therapy and the eradication rates of two groups were compared.Results The eradication rate of quadruple regimen ＋ dental treatment group was 85.9%（55/64） while that of the other group 72.5% （29/40） （P = 0.091 ）.Conclusion The PPI ＋ bismuth quadruple regimen plus dental plaque removal procedures as rescue treatment may boost the eradication rate of refractory H.pylori infection patients.And the furazolidone quadruple therapy can be chosen for the treatment of refractory H.pylori infection.Oral H.pylori infection may play a role in the failure of H.pylori infection treatment.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2011年第12期836-839,共4页
National Medical Journal of China
关键词
幽门螺杆菌
口腔洁治
根除
Helicobacter pylori
Dental plaque removal procedure
Eradication rate
