摘要
目的运用系统评价方法评价芦荟联合外用预防输液性静脉炎的效果。方法检索PudMed/MEDLINE、Cochrane图书馆、CNKI、维普、万方、中医药在线、中国生物医学文献数据库,收集芦荟联合外用预防静脉炎的随机对照试验为研究对象,采用RevMan 5.0软件进行效应值（相对危险度RR）的统计分析方法。结果共12篇芦荟联合外用文献2 561例患者符合纳入标准。根据意向治疗分析显示：与单一芦荟、硫酸镁、马玲薯外敷或不处理等相比,芦荟联合外用预防输液性静脉炎均有明显效果,合并的RR值（95%可信区间）分别为0.23（0.19-0.27）。经过亚组分析,芦荟联合冰敷疗法预防静脉炎效果显著（RR=0.19,95%,CI：0.15-0.25）,优于其他联合。漏斗图显示散点分布较为集中,但不对称分布,提示纳入文献存在发表性偏倚。另外,芦荟外用其他指标显示,可减轻炎症发生程度,延长静脉留置针的留置时间。所有研究均未报道不良反应。结论芦荟联合不同形式（冰敷、马铃薯、药物）外用与单一应用芦荟、硫酸镁或不处理等相比,预防输液性静脉炎具有更好的疗效,确切的结论尚需要设计更为严谨的大样本临床试验进行验证。
Objective To assess the effect of externally-applied aloe in preventing the transfusion phlebitis in the systematic review of randomized-controlled trials（RCTs）.Methods Data regarding randomized-controlled trials（RCT） of the externally-applied aloe to prevent the transfusion phlebitis were collected from Pubmed/Medline,Cochrane library,CNKI,Chinese Medicine on line,CBMdisc.The values of relative risk（RR） were analyzed by RevMan 5.0.Results Twelve articles involving 2 561 patients were included.Compared with the control groups,the combination of externally-applied aloe with other substances（ice,potatoes,drugs） produced a significant difference in preventing the transfusion phlebitis.The RRs（95%CI） respectively were 0.23（0.19~0.27）.In subgroup analysis,the effect of aloe combined ice therapy to prevent phlebitis was significant（RR=0.19,95% CI：0.15~0.25）,better than any other treatment,In addition,the external application of aloe extended the retention time of intravenous catheters.No adverse reactions were reported in the collected data.Conclusion Compared with an application of aloe or magnesium sulfate alone or no treatment,the combination of externally-applied aloe with other substances（ice,potatoes,drugs） is more effective in preventing transfusion phlebitis.But a more definite conclusion requires high-quality and large-sample RCTs.
出处
《福建医科大学学报》
2011年第1期45-49,共5页
Journal of Fujian Medical University
