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IL-17在缺血再灌注损伤中作用的研究进展 被引量：12

The Role of IL-17 in Ischemia Reperfusion Injury
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摘要 缺血再灌注损伤(ischemia reperfusion injury,IRI)是指局部组织器官的血流供应被阻断,当血流再灌注时会发生相应的损伤加重的情况。以往人们对缺血再灌注损伤机制的研究着重于氧自由基损伤、能量代谢、细胞内钙超载、白细胞黏附与内皮细胞损伤等理论,而目前细胞因子在IRI中的作用越来越被关注,其中最新研究表明Th17细胞所分泌的IL-17在IRI过程中起到重要作用,现将这方面的最新研究进展做一概述。 In ischemia reperfusion,blood supply to tissues and organs was blocked,and blood flowing can aggravate the situation of tissue injury during reperfusion.In the past,studies were focused on the oxygen free radical damage,energy metabolism,intracellular calcium overload,leukocyte adhesion,endothelial cell injury and other theories about ischemia-reperfusion injury（IRI） mechanism.However,the role of cytokines in IRI is increasingly reported recently.The latest research shows that IL-17-secreting Th17 cells play an important role in the process of IRI.In this article,the roles of Thl7 cells and the cytokine IL-17 in ischemia-reperfusion injury are summarized.【
作者 朱伟伟 王鹏程 李小松
机构地区 首都医科大学附属北京儿童医院外科
出处 《首都医科大学学报》 CAS 北大核心 2011年第2期304-308,共5页 Journal of Capital Medical University
基金 北京市自然科学基金(7092029) 北京市优秀人才资助计划(20081D0300800084)~~
关键词 缺血再灌注损伤 细胞因子 免疫损伤 ischemia-reperfusion injury cytokine immunolesion
分类号 R657.3 [医药卫生—外科学]
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参考文献26

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二级参考文献79

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共引文献14

同被引文献130

引证文献12

二级引证文献92

首都医科大学学报
2011年 第2期

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