摘要
背景:半月板损伤是常见的膝关节运动损伤之一,常伴有关节软骨的损伤,其原因是膝关节内环境的紊乱。目的:评价组织工程半月板在半月板构建中的生物支架材料的性能,以寻求合理的半月板替代物。方法:以"组织工程;半月板修复;生物材料支架;运动性半月板损伤"为中文关键词,以"tissue engineering,the meniscus repair,biological material scaffold;athletic meniscal injury"为英文关键词,应用计算机检索维普数据库(1994-01/2009-12)和Pubmed数据库(1994-01/2009-12),纳入30篇运动性半月板损伤和组织工程半月板相关的文献。对半月板组织的特征、半月板组织工程种子细胞的来源、组织工程半月板支架材料生物相容性和可降解性以及细胞因子在组织工程半月板构建过程中的作用进行综合评价。结果与结论:与传统半月板修复相比,组织工程化半月板具有无抗原性,来源不受限制,可按预先设计塑型,具有生命力等许多优点。但是组织工程化半月板仍有许多问题有待研究和解决,如何模拟体内环境,在体外成功构建半月板组织,如何提高支架材料的应用性,研制具有与正常人体半月板组织相接近的力学性能的支架材料是一个半月板修复的关键性问题。
BACKGROUND： Meniscus injury is a common sports injury of the knee joint, often accompanied by relevant cartilage damage, the reason is the environment disorders within the knee joint. OBJECTIVE： To seek reasonable meniscus alternatives by evaluating performance of biological scaffold material in tissue-engineered meniscus construction. METHODS： Databases of VIP and PubMed were searched by computer using key words of ＂tissue engineering, the meniscus repair, biological material scaffold, and athletic meniscal injury＂ from January 1994 to December 2009. Totally 30 papers related to exercise-induced meniscus injury and application of tissue-engineered meniscus were included. The features of meniscus, sources of seed cells for tissue-engineered meniscus, biocompatibility and degradability of tissue-engineered meniscus, as well as the role of cytokine in tissue-engineered meniscus construction were evaluated. RESULTS AND CONCLUSION： Compared with the traditional meniscus repair, tissue-engineered meniscus is characterized by no antigenicity, not restricted sources, pre-designed plastic and high vitality. However, there are still many problems to be solved in the tissue-engineered meniscus field, such as, how to construct meniscus tissue by simulating in vivo environment, how to improve the application of scaffold materials, and how to prepare a scaffold that has similar mechanical properties of normal human meniscus tissues.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第11期2044-2046,共3页
Journal of Clinical Rehabilitative Tissue Engineering Research
