摘要
目的比较氟尿嘧啶(5-Fu)常规化疗与中人氟安局部植入缓释给药对荷HepA肝癌实体瘤小鼠肿瘤切除术后的复发率。方法昆明种小鼠48只,随机分为3组,接种HepA瘤细胞,5 d后手术切除瘤结。A组直接缝合切口;B组将5-Fu注射液用生理盐水配成浓度为2 g/L的溶液,用浸泡有药液的棉球置于瘤床处15 min后缝合切口;C组于瘤旁植入中人氟安,剂量为3 mg/只,缝合切口。记录各组小鼠肿瘤复发情况并统计分析。结果 C组肿瘤未复发率显著高于A、B组(P<0.05),其肿瘤重量与A组比较差异有统计学意义(P<0.05)。结论中人氟安局部植入缓释给药化疗疗效明显优于传统的常规化疗。
Objective To investigate the tumor recurrence rate of hepatocellular carcinoma（HepA）mice after operated excision with ip 5-fluorouracil（5-Fu） traditional general cancer chemotherapy or implanting Sino Fuan in local.Methods The mice were transplanted HepA and the tumour knots were operated excision five days later.These mice were divided into three groups：the model group,the ip 5-Fu group and the group of Sino Fuan implanted in local.Then the recurrence datas of all mice were analysed.Results The unrecurrence rate of implanted Sino Fuan in local group was salience higher than the model group and the ip 5-Fu group（P〈0.05）.The tumor weight of implanted Sino Fuan group also had salience difference with the model group（P〈0.05）.Conclusion Sino Fuan implanted in local has a patency better curative effect than 5-Fu traditional general cancer chemotherapy.
出处
《安徽医科大学学报》
CAS
北大核心
2011年第5期452-454,共3页
Acta Universitatis Medicinalis Anhui
基金
国家科技部快速反应支持项目(编号:2002-51)
关键词
氟尿嘧啶
药物植入物
肝肿瘤
实验性
fluorouracil
drug implants
liver neophasms
experimental
