摘要
目的:探讨60岁以上老年冠心病患者行冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后氯吡格雷抵抗的发生率和影响因素。方法:符合入选标准的患者208例,年龄61～80岁,根据对氯吡格雷的反应分为氯吡格雷抵抗组55例和氯吡格雷有反应组153例。结果:氯吡格雷抵抗的发生率26.4%。氯吡格雷抵抗组和有反应组血小板聚集率(platelet aggregation rate,PAR)分别为(57±6)%和(35±9)%(P<0.01)。多因素logistic回归分析提示Ⅱ型糖尿病[P=0.037,优势比(OR)=2.053,95%置信区间1.045-4.034]是氯吡格雷抵抗的影响因素。结论:60岁以上老年冠心病患者PCI术后氯吡格雷抵抗的发生率26.4%,Ⅱ型糖尿病是氯吡格雷抵抗的影响因素。
AIM： To assess the incidence and risk factors of clopidogrel resistance after percutaneous coronary intervention（PCI） with drug-eluting stent in patients 〉60 years of age.METHODS： The clinical data of 208 patients were collected,among whom 55 patients whose PAR 〉50% after PCI were assigned to the clopidogrel resistance group and the other 153 patients were assigned to the without resistance group.Correlation factors were analyzed and compared between groups.RESULTS： The incidence of clopidogrel resistance was 26.4% in elderly patients.The level of PAR was（57±6）% vs.（35±9）%（P〈0.01） between the two groups after PCI.Multivariate logistic regression models found that the risk factor was diabetes mellitus（P=0.037,OR 2.053,95% CI 1.045-4.034）.CONCLUSION： The incidence of clopidogrel resistance is 26.4% after PCI with drug-eluting stent in patients 60 years of age,and diabetes mellitus is the risk factor for clopidogrel resistance.
出处
《心脏杂志》
CAS
2011年第2期224-226,共3页
Chinese Heart Journal
