摘要
目的：探讨雌二醇受体（ Ｅ Ｒ） 数量与绝经后Ⅱ型糖尿病的关系。方法：选测绝经后Ⅱ型糖尿病患者４２ 例和６０ 例正常妇女（ 绝经前后各３０ 例） 。采用放射配体法检测外周血白细胞 Ｅ Ｒ 含量；采用放射免疫法检测血浆雌二醇（ Ｅ２） 浓度。结果：绝经后Ⅱ型糖尿病患者组白细胞 Ｅ Ｒ 及血浆 Ｅ２ 显著低于正常绝经前组（ Ｐ＜ ０ ．０１） ，且较正常绝经后组也明显下降（ Ｐ＜ ０ ．０１） 。结论：绝经后Ⅱ型糖尿病的发病可能与雌二醇及 Ｅ Ｒ 的降低有关。
Objective:To study the relations between estradiol receptor(ER) level and postmenopausal non insulin dependent diabetes mellitus(NIDDM).Methods:In 42 women with postmenopausal NIDDM(group A) and 30 normal controls after menopause(group B) and 30 normal controls before menopause(group C) the ER contents on white blood cells and plasma estradiol(E\-2) concentrations were measured with radioimmunoassay.Results:Not only the E\-2 and ER in group A were very remarkably lower than those in group C( P <0.01),but were also apparently lower than those in group B( P <0.01).Conclusions:The reduction of E\-2 and ER is responsible for the incidence of postmenopausal NIDDM.
出处
《蚌埠医学院学报》
CAS
1999年第6期406-407,共2页
Journal of Bengbu Medical College
关键词
糖尿病
受体
雌激素
绝经后
Ⅱ型
diabetes mellitus,non insulin dependent
receptors,estrogen
estradiol
