摘要
目的分析个体化确定肺癌放疗ITV的必要性和应用千伏锥形束CT(kVCBCT)个体化确定肺癌放疗ITV的可行性。方法选择14例周围型肺癌患者进入研究。每位患者行1次常规定位CT扫描和3次kVCBCT扫描。根据常规定位CT勾画的可见肿瘤病灶为GTV,以GTV为基础,根据肿瘤所在肺叶的位置,外扩固定边界形成IGTV,称之为IGTV-p;根据kVCBCT勾画的可见肿瘤形成IGTV-c。GTV、IGTV-p和IGTV-c分别外扩5 mm,形成CTV、ITV-p和ITV-c。比较ITV-p和ITV-c的体积;ITV-p叠ITV-c体积;比较CTV和ITV-c的体积;以COM/SUM比值为参数,评价kVCBCT确定ITV的重复性。结果患者ITV-p和ITV-c的体积分别为(150.1±87.3)cc与(88.0±54.3)cc,二者比较,差异有明显统计学意义(P<0.0001)。ITV-p叠ITV-c体积为(67.1±32.4)cc。CTV与ITV-c比较,二者差异具有统计学意义(P=0.005);COM/SUM比值为(63.0±8.2)%。结论根据常规定位CT,"群体化"确定肺癌放疗ITV存在不足,锥形束CT可以用于个体化确定肺癌放疗的ITV。
Objective To assess the role of kilovoltage cone-beam CT（kVCBCT） in determining individual ITV for lung cancer patient.Methods Fourteen patients pathologically confirmed peripheral non-small cell lung cancer were entered into this study.One conventional planning CT and three kVCBCT scans were performed during quiet respiration for each patient.kVCBCT were all aligned to the conventional planning CT.After contouring GTV/IGTV,5 mm margin was performed to generate CTV/ITV.The volume of ITV-p（generated from conventional planning CT） and ITV-c（generated from kVCBCT） were compared.Overlap volume of ITV-p and ITV-c were documented.The volume of CTV and ITV-c were compared with each other.The reproducibility of the kVCBCT was evaluated using the ratio of COM/SUM.Results The volume of ITV-p and ITV-c had statistics significant difference（P0.0001）.The overlap volume of ITV-p and ITV-c was 67.1 cc.The volume of CTV and ITV-c had statistics significant difference（P=0.005）.The COM/SUM ratio of three ITVs which were defined from different kVCBCT scans was 63.0%±8.2%.Conclusion KVCBCT plays an important role in capturing the tumor movement and determine the individual ITV for lung cancer patient.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第4期437-439,共3页
Cancer Research on Prevention and Treatment
关键词
锥形束CT
内在靶体积
肺肿瘤
Cone-beam CT
Internal target volume
Lung neoplasm
