摘要
目的:检测白细胞介素-1β(IL-1β)和地塞米松(DEX)对体外培养的口腔正常黏膜与口腔扁平苔藓(OLP)黏膜成纤维细胞增殖的影响。方法:应用MTT法检测3种浓度梯度的IL-1β和DEX对体外培养的14例OLP黏膜成纤维细胞和11例正常口腔黏膜成纤维细胞增殖活性的影响。结果:MTT测定结果显示,IL-1β对OLP黏膜成纤维细胞和正常口腔黏膜成纤维细胞的增殖均有促进作用,且随浓度增加促进作用增强;相反,DEX却抑制两种成纤维细胞的增殖,浓度越高抑制作用越强。结论:白细胞介素-1β可促进成纤维细胞的增殖,地塞米松则抑制成纤维细胞的增殖。
Objective：To detect the influence of IL-1β and DEX on the proliferation of cultured fibroblasts from normal oral mucosa and oral lichen planus mucosa.Method：IL-1β and DEX of three concentration gradient were set and added to cultured fibroblasts of normal oral mucosa and oral lichen planus mucosa.MTT was adopted to assess the effects of IL-1β and DEX on the proliferation of fibroblasts.Result：IL-1 can promote the proliferation of both oral lichen planus fibroblasts and normal oral mucosa fibroblasts,and it is concentration-dependent.Otherwise,DEX inhibited the proliferation of the two kinds of fibroblasts,and it＇s also concentration dependent.Conclusion：Interleukin-1 could promote fibroblast proliferation,and dexamethasone inhibit fibroblast proliferation.
出处
《临床口腔医学杂志》
2011年第4期199-201,共3页
Journal of Clinical Stomatology
