摘要
目的 从转化医学角度分析高压氧治疗（hyperbaric oxygen therapy,HBOT）对颅脑创伤患者的治疗作用,并评估不同治疗疗程和时机对疗效的影响.方法 本文回顾性分析自2003年3月至2010年10月联合采用HBOT满30次以上的颅脑创伤住院患者138例和同期未行HBOT者29例,评估高压氧不同治疗疗程和时机对格拉斯哥昏迷评分（glasgow coma scale,GCS）的改善作用,并结合前期相关实验研究对比分析.结果 联合HBOT的患者GCS评分由（8.06±1.68）分提高到（12.54±1.54）分,提高（4.45±2.85）分;不行HBOT的患者GCS评分由（7.86±2.85）分提高到（10.24±2.39）分,提高（2.38±2.16）分（P＜0.01）.HBOT 50次以上者GCS评分由（7.50±1.67）分提高到（13.15±1.08）分,提高（5.66±3.14）分;50次以下者GCS评分由（8.40±1.61）分提高到（12.16±1.66）分,提高（3.72±2.40）分（P＜0.01）.颅脑伤后1个月内开始行HBOT者GCS评分由（7.50±1.80）分提高到（12.76±1.77）分,提高（5.25±2.80）分;受伤1个月以后开始行HBOT者GCS评分（8.84±1.24）分提高到（12.22±0.98）分,提高（3.34±2.44）分（P＜0.01）.结论 颅脑创伤患者在常规治疗的基础上,应该尽早开始HBOT,疗程最好不少于30次,条件允许可延长治疗时间到50次,可显著改善患者的GCS评分.
Objective To evaluate the effects of hyperbaric oxygen therapy （HBOT） on Glasgow Coma Scale（GCC） after traumatic brain injury（TBI） in patients. Method One hundred and thirty eight patients with traumatic brain injury were treated by routine therapy combined with HBOT and 29 patients by routine therapy. Influences of different treatment sessions and therapeutic window on the improvement of GCS were analyzed. Results The GCS improvement of patients treated by combined therapy was （4. 45 ± 2. 85）,which was higher than that （2. 38 ±2. 16） without HBOT. In the patients who received the treatment more than 50 times,the score raised by （5.66 ±3. 14） ,which was more than that（3.72 ±2.40） of the patients whose treatment number was less than 50 times. In the 138 TBI patients with conscious disturbance,GCS increased by （5.25 ±2.80） in those who received HBOT in 30 days after TBI, and by （3. 34 ± 2. 44） in those 30 days post -injury.Conclusions HBOT should be initiated as early as possible except for the routine therapy. The course of HBOT should better not be less than 30 times in patients with conscious disturbance.
出处
《中华神经外科杂志》
CSCD
北大核心
2011年第3期232-235,共4页
Chinese Journal of Neurosurgery
基金
卫生部卫生公益性行业科研专项（200902004）
国家自然科学基金资助项目（81000532,30973100）
关键词
颅脑损伤
高压氧
格拉斯哥昏迷量表
转化医学
Craniocerebral trauma
Hyperbaric oxygenation
Glasgow coma scale
Translational medcine
